Multi-step reaction with 6 steps
1.1: potassium hydroxide / ethylene glycol / 18 h / 95 °C
2.1: palladium(II) hydroxide; hydrogen / methanol; tetrahydrofuran / 120 h / 45 °C / 2585.81 Torr
3.1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C
4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C
5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 - 20 °C
6.1: acetic acid / methanol / 0.5 h / 6 - 20 °C
6.2: 4 h / 55 °C
With
hydrogenchloride; hydrogen; palladium(II) hydroxide; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;