8-OXA-3-AZABICYCLO[3.2.1]OCTANEHYDROCHLORIDE

Base Information

• Chemical Name: 8-OXA-3-AZABICYCLO[3.2.1]OCTANEHYDROCHLORIDE
• CAS No.: 54745-74-3
• Molecular Formula: C6H12ClNO
• Molecular Weight: 149.62
• Hs Code.: 2934999090
• Mol file: 54745-74-3.mol

Synonyms:8-Oxa-3-azabicyclo[3.2.1]octane,hydrochloride (9CI);

Chemical Property of 8-OXA-3-AZABICYCLO[3.2.1]OCTANEHYDROCHLORIDE

Chemical Property:

• Melting Point: 197-199 °C
• PSA: 21.26000
• LogP: 1.26800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Oxa-3-azabicyclo[3,2,1]octanehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Oxa-3-azabicyclo[3.2.1]octane hydrochloride is employed as a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Technology Process of 8-OXA-3-AZABICYCLO[3.2.1]OCTANEHYDROCHLORIDE

There total 5 articles about 8-OXA-3-AZABICYCLO[3.2.1]OCTANEHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

8-oxa-3-azabicyclo[3.2.1]octane-2,4-dione → 8-oxa-3-azabicyclo[3.2.1]octane hydrochloride (54745-74-3)

Guidance literature:

8-oxa-3-azabicyclo[3.2.1]octane-2,4-dione; With borane-THF; at 67 ℃; for 2h;

With hydrogenchloride; In methanol; water; at 70 ℃; for 3h;

DOI:10.1039/c6ra08737j

Reference yield:

3-benzyl-8-oxa-3-aza-bicyclo[3.2.1]octane (54745-75-4) → 8-oxa-3-azabicyclo[3.2.1]octane hydrochloride (54745-74-3)

Guidance literature:

3-benzyl-8-oxa-3-aza-bicyclo[3.2.1]octane; With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; In 1,2-dichloro-ethane; Heating / reflux;

With hydrogenchloride; In ethanol; water;

Reference yield:

furan-2,5-dicarboxylic acid (3238-40-2) → 8-oxa-3-azabicyclo[3.2.1]octane hydrochloride (54745-74-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen; acetic acid / 69 h / 60 °C

1.2: 0.5 h / 20 °C

2.1: 6 h / 230 °C

3.1: borane-THF / 2 h / 67 °C

3.2: 3 h / 70 °C

With borane-THF; palladium on activated charcoal; hydrogen; acetic acid;

DOI:10.1039/c6ra08737j

upstream raw materials:

3-benzyl-8-oxa-3-aza-bicyclo[3.2.1]octane

furan-2,5-dicarboxylic acid

Downstream raw materials:

3-phenylacetyl-8-oxa-3-aza-bicyclo[3.2.1]octane

1-(1-benzyl-piperidin-4-yl)-6-chloro-4-(8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine

6-chloro-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine

C₂₄H₂₅F₂N₇O₂

Refernces

• 1、 -. "THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS". Page/Page column 63. . Retrieved 2009/04/24.