5-(BROMOACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 97

Base Information

• Chemical Name: 5-(BROMOACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 97
• CAS No.: 105316-98-1
• Molecular Formula: C10H8BrNO2
• Molecular Weight: 254.08002
• Hs Code.: 2933790090
• Mol file: 105316-98-1.mol

Synonyms:2H-Indol-2-one,5-(bromoacetyl)-1,3-dihydro- (9CI);5-(2-Bromoacetyl)-1,3-dihydroindol-2-one;5-(2-Bromoacetyl)indolin-2-one;

Chemical Property of 5-(BROMOACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 97

Chemical Property:

• Vapor Pressure: 1.27E-08mmHg at 25°C
• Melting Point: 225 °C
• Refractive Index: 1.624
• Boiling Point: 459.4 °C at 760 mmHg
• Flash Point: 231.6 °C
• PSA: 46.17000
• Density: 1.631 g/cm³
• LogP: 1.89680

Purity/Quality:

99% ^*data from raw suppliers

5-(Bromoacetyl)-2-oxoindoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(BROMOACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 97

There total 3 articles about 5-(BROMOACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-oxoindole (59-48-3) → 5-(bromoacetyl)-1,3-dihydro-2H-indol-2-one (105316-98-1)

Guidance literature:

2-Bromoacetyl bromide; aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 1h;

2-oxoindole; In 1,2-dichloro-ethane; at 0 - 50 ℃; for 5h;

Reference yield:

2-oxoindole (59-48-3) + 2-bromoacetyl chloride (22118-09-8) → 5-(bromoacetyl)-1,3-dihydro-2H-indol-2-one (105316-98-1)

Guidance literature:

AlCl₃; In dichloromethane;

Reference yield:

2-oxoindole (59-48-3) + 2-Bromoacetyl bromide (598-21-0) → 5-(bromoacetyl)-1,3-dihydro-2H-indol-2-one (105316-98-1)

Guidance literature:

aluminium trichloride; In water; 1,2-dichloro-ethane;

upstream raw materials:

2-oxoindole

2-Bromoacetyl bromide

2-bromoacetyl chloride

Refernces

• 1、 -. "SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS". . . Retrieved 2008/06/13.
• 2、 -. "6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses". . . Retrieved 2008/06/13.