2-BROMO-3-FLUOROBENZALDEHYDE

Base Information

• Chemical Name: 2-BROMO-3-FLUOROBENZALDEHYDE
• CAS No.: 149947-15-9
• Molecular Formula: C7H4BrFO
• Molecular Weight: 203.011
• Hs Code.: 2913000090
• Mol file: 149947-15-9.mol

Synonyms:3-Bromo-2-fluorobenzaldehyde;

Chemical Property of 2-BROMO-3-FLUOROBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.0779mmHg at 25°C
• Melting Point: 43-46 °C
• Refractive Index: 1.584
• Boiling Point: 233.655 °C at 760 mmHg
• Flash Point: 95.111 °C
• PSA: 17.07000
• Density: 1.685 g/cm³
• LogP: 2.40070
• Storage Temp.: Room temperature.
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

3-Bromo-2-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-3-FLUOROBENZALDEHYDE

There total 7 articles about 2-BROMO-3-FLUOROBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-bromo-2-fluoro-3-(hydroxymethyl)benzene (261723-32-4) → 3-bromo-2-fluorobenzaldehyde (149947-15-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 45 ℃;

Reference yield: 73.0%

o-fluorobromobenzene (1072-85-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-bromo-2-fluorobenzaldehyde (149947-15-9)

Guidance literature:

o-fluorobromobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; for 1.16667h;

Reference yield:

o-fluorobromobenzene (1072-85-1) + N,N-diethyl-3,4-difluorobenzamide (130286-84-9) → 3-bromo-2-fluorobenzaldehyde (149947-15-9)

Guidance literature:

With thionyl chloride; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

o-fluorobromobenzene

N,N-diethyl-3,4-difluorobenzamide

1-bromo-3-(bromomethyl)-2-fluorobenzene

1-bromo-2-fluoro-3-(hydroxymethyl)benzene

Downstream raw materials:

C₇H₅BrFNO

C₁₅H₉FO

beraprost 314d

Refernces

• 1、 -. "Method for rapidly synthesizing 3-bromo-2-fluorobenzaldehyde based on continuous flow reaction technology". Paragraph 0008; 0019-0022. . Retrieved 2021/08/19.
• 2、 -. "N-(piperidin-4-yl)benzo[b]thiophenecarboxamide derivatives, preparation method therof, and pharmaceutical composition for use in preventing or treating Urotensin-Ⅱ receptor activity related diseases containing the same as an active ingredient". Paragraph 0181; 0182; 0183; 0184. . Retrieved 2016/10/10.