2-Fluoro-6-nitrobenzaldehyde

Base Information

• Chemical Name: 2-Fluoro-6-nitrobenzaldehyde
• CAS No.: 1644-82-2
• Molecular Formula: C7H4FNO3
• Molecular Weight: 169.112
• Hs Code.: 2913000090
• European Community (EC) Number: 962-498-4
• DSSTox Substance ID: DTXSID40542898
• Nikkaji Number: J1.367.537F
• Wikidata: Q72475174
• Mol file: 1644-82-2.mol

Synonyms:2-Fluoro-6-nitrobenzaldehyde;1644-82-2;Benzaldehyde, 2-fluoro-6-nitro-;C7H4FNO3;2-nitro-6-fluorobenzaldehyde;2-Fluoro-6-nitro-benzaldehyde;MFCD09835320;Benzaldehyde,2-fluoro-6-nitro-;3-FLUORO-2-FORMYLNITROBENZENE;SCHEMBL101394;AMY4703;DTXSID40542898;LMTKLMMRJDNPFT-UHFFFAOYSA-N;CL8983;AKOS006329404;DS-1803;SY035406;EN300-194217;A856797;Z1198233568

Chemical Property of 2-Fluoro-6-nitrobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00257mmHg at 25°C
• Melting Point: 62-63℃
• Refractive Index: 1.59
• Boiling Point: 286.9 °C at 760 mmHg
• Flash Point: 127.3 °C
• PSA: 62.89000
• Density: 1.443 g/cm³
• LogP: 2.06960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 169.01752115
• Heavy Atom Count: 12
• Complexity: 192

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-6-nitrobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)F)C=O)[N+](=O)[O-]

Technology Process of 2-Fluoro-6-nitrobenzaldehyde

There total 10 articles about 2-Fluoro-6-nitrobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(bromomethyl)-1-fluoro-3-nitrobenzene (1958-93-6) → 2-fluoro-6-nitrobenzaldehyde (1644-82-2)

Guidance literature:

With 4 A molecular sieve; 4-methylmorpholine N-oxide; In acetonitrile; at 20 ℃;

Reference yield: 75.0%

2-(bromomethyl)-4-fluoro-1-nitrobenzene (82420-35-7) → 2-fluoro-6-nitrobenzaldehyde (1644-82-2)

Guidance literature:

With 4-methylmorpholine N-oxide; In acetonitrile; at 20 ℃; Molecular sieve;

Reference yield: 55.0%

(2-fluoro-6-nitrophenyl)methanol (1643-60-3) → 2-fluoro-6-nitrobenzaldehyde (1644-82-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2021.113843

upstream raw materials:

C₁₅H₁₄FN₃O₃

(2-fluoro-6-nitrophenyl)methanol

1-fluoro-2-methyl-3-nitrobenzene

2-(bromomethyl)-1-fluoro-3-nitrobenzene

Downstream raw materials:

10-[6-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-β-D-galacto-non-2-ulopyranosylonate)hexyl]-6-nitro-3-phenyl-5-deazaflavin

10-[6-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosylonate)hexyl]-6-nitro-3-phenyl-5-deazaflavin

methyl 4-nitrobenzo[b]thiophene-2-carboxylate

4-nitro-benzo[b]thiophene-2-carboxylic acid

Refernces

• 1、 -. "1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS". Page/Page column 62. . Retrieved 2010/04/03.
• 2、 -. "Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents". . . Retrieved 2008/06/13.