Methyl 2-fluoroacrylate

Base Information

• Chemical Name: Methyl 2-fluoroacrylate
• CAS No.: 2343-89-7
• Molecular Formula: C4H5FO2
• Molecular Weight: 104.081
• Hs Code.: 29161290
• European Community (EC) Number: 607-233-2
• UNII: 3P6DG2B57G
• DSSTox Substance ID: DTXSID80382134
• Nikkaji Number: J107.328A
• Wikipedia: Methyl 2-fluoroacrylate
• Wikidata: Q18344142
• Mol file: 2343-89-7.mol

Synonyms:methyl 2-fluoroacrylate;2343-89-7;Methyl 2-fluoroprop-2-enoate;Methyl-2-fluoroacrylate;2-Fluoroacrylic acid methyl ester;2-Propenoic acid, 2-fluoro-, methyl ester;Methyl 2-fluoroacrylate, BHT stabilized;3P6DG2B57G;MFCD04039286;EC 607-233-2;METHYL2-FLUOROACRYLATE;Methyl a-fluoroacrylate;Methyl 2-Fluorocrylate;methyl alpha-fluoroacrylate;UNII-3P6DG2B57G;SCHEMBL98866;Methyl 2-fluoroacrylate, 95%;a-Fluoroacrylic acid methyl ester;DTXSID80382134;ZTZJVAOTIOAZGZ-UHFFFAOYSA-N;2-fluoro-acrylic acid methyl ester;CS-B0596;3-Amino-4,5-dichloro-benzoic acid;AKOS005259600;GS-3631;SY044794;Methyl 2-fluoroacrylate stab. with 1% BHT;AM20120633;FT-0660844;M3179;EN300-41578;.ALPHA.-FLUOROACRYLIC ACID METHYL ESTER;ACRYLIC ACID, 2-FLUORO-, METHYL ESTER;J-522660;Q18344142;31344-36-2

Chemical Property of Methyl 2-fluoroacrylate

Chemical Property:

• Vapor Pressure: 103mmHg at 25°C
• Refractive Index: 1.39
• Boiling Point: 75.9 °C at 760 mmHg
• Flash Point: 1.1 °C
• PSA: 26.30000
• Density: 1.057 g/cm³
• LogP: 0.64260
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 104.02735756
• Heavy Atom Count: 7
• Complexity: 97.9

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-Fluoroacrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C(=C)F
• Uses: Methyl 2-fluoroacrylate is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Technology Process of Methyl 2-fluoroacrylate

There total 35 articles about Methyl 2-fluoroacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 1,2,3,3-tetrafluoro-2-propene (115781-23-2) → methyl 2-fluoroprop-2-enoate (2343-89-7) + C4H5F3O

Guidance literature:

With potassium hydroxide; In water; N,N-dimethyl-formamide; at 120 ℃; for 2h; Reagent/catalyst; Temperature;

Reference yield: 95.0%

methyl 2-fluoro-3-chloropropionate (55900-27-1) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; sodium phosphate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; under 112.511 - 225.023 Torr;

Reference yield: 93.0%

methanol (67-56-1) + 2-fluoroacrylic acid (430-99-9) → methyl 2-fluoroprop-2-enoate (2343-89-7)

Guidance literature:

With thionyl chloride; at 5 - 35 ℃; for 2h; Concentration; Reagent/catalyst;

upstream raw materials:

methyl 3-bromo-2-fluoro-2-chloropropanoate

methyl 3-bromo-2-fluoropropionate

methyl 2-fluoro-3-chloropropionate

methyl α,β-dibromo-α-fluoropropionate

Downstream raw materials:

2-fluoro-3-phenyl acrylic acid methyl ester

Refernces

• 1、 -. "SYNTHESIS OF METHYL 2-FLUOROACRYLATE". Paragraph 00119. . Retrieved 2021/10/02.
• 2、 -. "ONE STEP SYNTHESIS FOR ALKYL 2-FLUOROACRYLATES". Paragraph 0073-0078. . Retrieved 2021/05/21.