(S)-3-N-Boc-3-(methylamino)piperidine

Base Information

• Chemical Name: (S)-3-N-Boc-3-(methylamino)piperidine
• CAS No.: 309962-63-8
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Hs Code.: 2933399090
• Mol file: 309962-63-8.mol

Synonyms:tert-Butyl N-[(3S)-piperidin-3-yl]glycinate;

Chemical Property of (S)-3-N-Boc-3-(methylamino)piperidine

Chemical Property:

• Vapor Pressure: 0.00242mmHg at 25°C
• Refractive Index: 1.485
• Boiling Point: 287.863 °C at 760 mmHg
• PKA: 9.74±0.10(Predicted)
• Flash Point: 127.895 °C
• PSA: 41.57000
• Density: 1.019 g/cm³
• LogP: 1.93410
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

(S)-tert-ButylMethyl(piperidin-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-tert-Butyl methyl(piperidin-3-yl)carbamate is a useful reactant for the synthesis substituted azoles, thiophenes and furans that act as sterol regulatory element-?binding proteins (SREBPs) inhibitors.

Technology Process of (S)-3-N-Boc-3-(methylamino)piperidine

There total 5 articles about (S)-3-N-Boc-3-(methylamino)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ methyl-(S)-piperidin-3-yl-carbamic acid tert-butyl ester (309962-63-8)

Guidance literature:

Reference yield: 93.0%

tert-butyl (3S)-1-(trifluoroacetyl)piperidinylcarbamate (309962-62-7) + methyl iodide (74-88-4) → methyl-(S)-piperidin-3-yl-carbamic acid tert-butyl ester (309962-63-8)

Guidance literature:

tert-butyl (3S)-1-(trifluoroacetyl)piperidinylcarbamate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With potassium carbonate; In methanol; at 20 ℃; for 16h;

Reference yield:

benzyl (3S)-3-[tert-butoxycarbonyl(methyl)amino]piperidine-1-carboxylate (1124199-24-1,1284966-16-0) → methyl-(S)-piperidin-3-yl-carbamic acid tert-butyl ester (309962-63-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 2h;

upstream raw materials:

tert-butyl (3S)-1-(trifluoroacetyl)piperidinylcarbamate

methyl iodide

tert-butyl (S)-piperidin-3-yl-carbamate

benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

Downstream raw materials:

2-(3,5-dichlorophenylamino)-1-((S)-3-(methylamino)piperidin-1-yl)ethanone

1-{(S)-3-[(2-aminopyrimidin-4-yl)methylamino]piperidin-1-yl}-2-(3,5-dichlorophenylamino)ethanone

tert-butyl methyl((S)-1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)carbamate

Refernces

• 1、 -. "HETEROCYCLIC TYROSINE KINASE INHIBITORS". . . Retrieved 2012/05/19.
• 2、 -. "Heterocyclic substituted aminoazacycles useful as central nervous system agents". Page 45. . Retrieved 2010/02/07.