C₁₉H₁₈ClN

Base Information

• Chemical Name: C₁₉H₁₈ClN
• CAS No.: 1620789-25-4
• Molecular Formula: C₁₉H₁₈ClN
• Molecular Weight: 295.812
• Mol file: 1620789-25-4.mol

Synonyms:C₁₉H₁₈ClN

Chemical Property of C₁₉H₁₈ClN

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₉H₁₈ClN

There total 1 articles about C₁₉H₁₈ClN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,6-dichloroisoquinoline (630421-73-7) + p-tert-butylphenylboronic acid (123324-71-0) → C19H18ClN (1620789-25-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 60 ℃; for 6h; Inert atmosphere;

Reference yield:

C19H18ClN (1620789-25-4) + 2-formylbenzene boronic acid (40138-16-7) → C26H23NO (1620789-26-5)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In water; toluene; at 130 ℃; for 5h;

Reference yield:

C19H18ClN (1620789-25-4) → C28H27NO (1620789-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 5 h / 130 °C

2.1: potassium tert-butylate / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

2.2: 16 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; water; toluene;

upstream raw materials:

1,6-dichloroisoquinoline

p-tert-butylphenylboronic acid

Downstream raw materials:

C₂₈H₂₇NO

C₂₇H₂₃N

C₂₆H₂₃NO

Refernces