methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

Base Information

• Chemical Name: methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride
• CAS No.: 1092794-07-4
• Molecular Formula: C₁₂H₁₅NO₂*ClH
• Molecular Weight: 241.718
• Mol file: 1092794-07-4.mol

Synonyms:methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

Chemical Property of methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

There total 2 articles about methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-cyanophenyl)cyclopropanecarboxylic acid methyl ester (1092794-06-3) → methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride (1092794-07-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h; under 1520.1 Torr;

Reference yield:

methyl 2-(2-cyanophenyl)acetate (20921-96-4) → methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride (1092794-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 1 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / 1520.1 Torr

With palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; sodium hydroxide; In ethanol; water; toluene;

Reference yield:

methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride (1092794-07-4) → 3-(2,6-dichlorophenyl)-4-imino-7-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one dihydrochloride

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydroxide / methanol; water / 0.5 h / 20 °C

2: sulfuric acid; potassium nitrate / 0.25 h / 20 °C

3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / Reflux

4: sodium cyanoborohydride; acetic acid / methanol; water / 15 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C / 760.05 Torr

6: toluene-4-sulfonic acid / butan-1-ol / 0.25 h / 90 °C

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; potassium nitrate; In tetrahydrofuran; methanol; ethanol; water; butan-1-ol;

upstream raw materials:

1-(2-cyanophenyl)cyclopropanecarboxylic acid methyl ester

methyl 2-(2-cyanophenyl)acetate

Downstream raw materials:

3-(2,6-dichlorophenyl)-4-imino-7-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one dihydrochloride

7’-nitro-2’,3’-dihydro-1’H-spiro[cyclopropane-1,4’-isoquinoline]

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR TREATING CANCER". Page/Page column 38-39. . Retrieved 2014/05/07.
• 2、 -. "BICYCLOANILINE DERIVATIVE". Page/Page column 42-43. . Retrieved 2010/04/25.