3-Amino-2-(2,4-difluorophenoxy)pyridine

Base Information

• Chemical Name: 3-Amino-2-(2,4-difluorophenoxy)pyridine
• CAS No.: 175135-63-4
• Molecular Formula: C11H8F2N2O
• Molecular Weight: 222.194
• Hs Code.: 2933399090
• European Community (EC) Number: 670-897-7
• DSSTox Substance ID: DTXSID90371014
• Nikkaji Number: J2.982.435E
• Wikidata: Q82158226
• ChEMBL ID: CHEMBL1608020
• Mol file: 175135-63-4.mol

Synonyms:175135-63-4;2-(2,4-difluorophenoxy)pyridin-3-amine;3-Amino-2-(2,4-difluorophenoxy)pyridine;CHEMBL1608020;Sodiumpersulfate;3-Pyridinamine, 2-(2,4-difluorophenoxy)-;Maybridge1_001738;MLS000851022;SCHEMBL400328;HMS546G22;DTXSID90371014;PC1070R;HMS2793C11;AMY28721;BDBM50559489;MFCD00067802;AKOS000138267;CCG-234963;PS-6384;SDCCGMLS-0065865.P001;2-(2,4-difluorophenoxy)-3-pyridinamine;SMR000457265;2-(2,4-Difluorophenoxy)pyridine-3-amine;CS-0313677;FT-0614917;E85503;A811738;W-206096;3-amino-2-(2,4-difluorophenoxy)pyridine, AldrichCPR

Chemical Property of 3-Amino-2-(2,4-difluorophenoxy)pyridine

Chemical Property:

• Vapor Pressure: 0.000185mmHg at 25°C
• Melting Point: 96 °C
• Refractive Index: 1.605
• Boiling Point: 301.2 °C at 760 mmHg
• Flash Point: 136 °C
• PSA: 48.14000
• Density: 1.355 g/cm³
• LogP: 3.31550
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 222.06046921
• Heavy Atom Count: 16
• Complexity: 230

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-2-(2,4-difluorophenoxy)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)OC2=C(C=C(C=C2)F)F)N
• Uses: 3-Amino-2-(2,4-difluorophenoxy)pyridine is used in the preparation of modulators of ATP-binding cassette transporters which are useful in the treatment of ABC-transporter-mediated diseases.

Technology Process of 3-Amino-2-(2,4-difluorophenoxy)pyridine

There total 3 articles about 3-Amino-2-(2,4-difluorophenoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(2,4-difluorophenoxy)-3-nitropyridine (175135-62-3) → 2-(2,4-difluorophenoxy)pyridin-3-amine (175135-63-4)

Guidance literature:

With sodium dithionite; water; In tetrahydrofuran; at 20 ℃; for 2.5h;

DOI:10.1248/cpb.59.1069

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-(2,4-difluorophenoxy)pyridin-3-amine (175135-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 °C / Reflux

2: sodium dithionite; water / tetrahydrofuran / 2.5 h / 20 °C

With sodium dithionite; water; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1248/cpb.59.1069

Reference yield:

2,4-difluorophenol (367-27-1) → 2-(2,4-difluorophenoxy)pyridin-3-amine (175135-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 °C / Reflux

2: sodium dithionite; water / tetrahydrofuran / 2.5 h / 20 °C

With sodium dithionite; water; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1248/cpb.59.1069

upstream raw materials:

2-Chloro-3-nitropyridine

2-(2,4-difluorophenoxy)-3-nitropyridine

2,4-difluorophenol

Downstream raw materials:

N-[2-(2,4-difluorophenoxy)-3-pyridyl]ethanesulfonamide

Refernces

• 1、 Nakayama, Hitoshi,Ishihara, Keiichi,Akiba, Satoshi,Uenishi, Jun'ichi. "Synthesis of N-[2-(2,4-difluorophenoxy)trifluoromethyl-3-pyridyl]- sulfonamides and their inhibitory activities against secretory phospholipase A2". . p. 1069 - 1072. Retrieved 2011/10/02.