Benzenamine, 2-chloro-3-methoxy-, hydrochloride

Base Information

• Chemical Name: Benzenamine, 2-chloro-3-methoxy-, hydrochloride
• CAS No.: 85893-87-4
• Molecular Formula: C7H8ClNO.HCl
• Molecular Weight: 194.06
• Hs Code.: 2922299090
• Mol file: 85893-87-4.mol

Synonyms:Benzenamine,2-chloro-3-methoxy-, hydrochloride (9CI);

Chemical Property of Benzenamine, 2-chloro-3-methoxy-, hydrochloride

Chemical Property:

• Boiling Point: 287.3 °C at 760 mmHg
• Flash Point: 127.5 °C
• PSA: 35.25000
• LogP: 3.31400
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-methoxyanilinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenamine, 2-chloro-3-methoxy-, hydrochloride

There total 2 articles about Benzenamine, 2-chloro-3-methoxy-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3-methoxy-N-pivaloylaniline (85893-97-6) → 2-chloro-3-methoxyaniline hydrochloride (85893-87-4)

Guidance literature:

With hydrogenchloride; In ethanol; for 6h; Yield given; Heating;

DOI:10.1021/jm00363a016

Reference yield:

N-(3-methoxyphenyl)pivalamide (56619-93-3) → 2-chloro-3-methoxyaniline hydrochloride (85893-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, 2.) hexachloroethane / 1.) THF, 0 deg C, 2 h, 2.) THF, from 0 deg C to RT, overnight

2: conc. HCl / ethanol / 6 h / Heating

With hydrogenchloride; n-butyllithium; hexachloroethane; In ethanol;

DOI:10.1021/jm00363a016

Reference yield: 74.0%

malonic acid (141-82-2) + 2-chloro-3-methoxyaniline hydrochloride (85893-87-4) → 2,4,8-trichloro-7-methoxyquinoline (893620-26-3)

Guidance literature:

With trichlorophosphate; for 16h; Heating / reflux;

upstream raw materials:

2-chloro-3-methoxy-N-pivaloylaniline

N-(3-methoxyphenyl)pivalamide

Downstream raw materials:

2,4,8-trichloro-7-methoxyquinoline

N-(2-chloro-3-methoxyphenyl)-2-hydroxyiminoacetamide

8-chloro-7-methoxy-4-(4-methoxy-benzyloxy)-2-(3-trifluoromethyl-1H-pyrazol-1-yl)-quinoline

4-(4-methoxybenzyloxy)-8-chloro-7-methoxy-2-(4-methylthiazol-2-yl)quinoline

Refernces