Technology Process of 3,4-bis(benzyloxy)-N-(3,3-diethoxypropyl)-benzamide
There total 3 articles about 3,4-bis(benzyloxy)-N-(3,3-diethoxypropyl)-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,4-bis(benzyloxy)benzoic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Inert atmosphere;
aminopropane diethyl acetal;
With
triethylamine;
In
N,N-dimethyl-formamide;
Inert atmosphere;
DOI:10.1002/anie.201005527
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: water; sodium hydroxide / methanol / 3 h / Reflux; Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: Inert atmosphere
With
water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201005527
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / Inert atmosphere
2.1: water; sodium hydroxide / methanol / 3 h / Reflux; Inert atmosphere
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
3.2: Inert atmosphere
With
water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201005527