21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione

Base Information

• Chemical Name: 21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione
• CAS No.: 1448329-07-4
• Molecular Formula: C₂₈H₃₁NO₄
• Molecular Weight: 445.558
• Mol file: 1448329-07-4.mol

Synonyms:21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione

Chemical Property of 21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione

There total 2 articles about 21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

pregna-1,4-diene-3,20-dione (1162-54-5) + 2-nitro-benzaldehyde (552-89-6) → 21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione (1448329-07-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/j.steroids.2013.04.016

Reference yield:

Progesterone (57-83-0) → 21E-(2-nitrobenzylidene)pregn-1,4-diene-3,20-dione (1448329-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 2 h / 0 °C / Reflux

2: potassium hydroxide / ethanol / 12 h / 20 °C

With tert-butyldimethylsilyl chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In 1,4-dioxane; ethanol;

DOI:10.1016/j.steroids.2013.04.016

upstream raw materials:

pregna-1,4-diene-3,20-dione

2-nitro-benzaldehyde

Progesterone

Refernces