Technology Process of 2H-3-Benzazepin-2-one, 1-amino-1,3,4,5-tetrahydro-3-methyl-, hydrochloride (1:1), (1S)-
There total 6 articles about 2H-3-Benzazepin-2-one, 1-amino-1,3,4,5-tetrahydro-3-methyl-, hydrochloride (1:1), (1S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-amino-3-methyl-1H,4H,5H-benzo-[d]azaperhydroepin-2-one;
With
(R)-Mandelic Acid;
In
Isopropyl acetate; isopropyl alcohol;
at 45 ℃;
for 3h;
With
5-Nitrosalicylaldehyde;
In
Isopropyl acetate; isopropyl alcohol;
for 13h;
With
hydrogenchloride; water;
In
ethyl acetate;
at 50 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 84 percent / H2; HCl / Pd/C / ethanol; H2O / 24 h / 50 °C / 12928.7 Torr
2.1: (-)-D-mandelic acid; 5-nitrosalicylaldehyde / isopropyl acetate; propan-2-ol / 45 °C
2.2: 61.4 percent / HCl / ethyl acetate; H2O / 4 h / 50 °C
With
hydrogenchloride; (R)-Mandelic Acid; hydrogen; 5-Nitrosalicylaldehyde;
palladium on activated charcoal;
In
ethanol; Isopropyl acetate; water; isopropyl alcohol;
DOI:10.1016/j.tetasy.2005.10.037
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 65.2 percent / AlCl3 / 1,2-dichloro-benzene / 2 h / 165 °C
2.1: 89 percent / isoamyl nitrite; lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0 - 20 °C
3.1: 84 percent / H2; HCl / Pd/C / ethanol; H2O / 24 h / 50 °C / 12928.7 Torr
4.1: (-)-D-mandelic acid; 5-nitrosalicylaldehyde / isopropyl acetate; propan-2-ol / 45 °C
4.2: 61.4 percent / HCl / ethyl acetate; H2O / 4 h / 50 °C
With
hydrogenchloride; aluminium trichloride; (R)-Mandelic Acid; hydrogen; 5-Nitrosalicylaldehyde; lithium hexamethyldisilazane; isopentyl nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; Isopropyl acetate; water; 1,2-dichloro-benzene; isopropyl alcohol;
1.1: Friedel-Crafts reaction;
DOI:10.1016/j.tetasy.2005.10.037