oct-3-ynoic acid

Base Information

• Chemical Name: oct-3-ynoic acid
• CAS No.: 57074-96-1
• Molecular Formula: C₈H₁₂O₂
• Molecular Weight: 140.182
• Mol file: 57074-96-1.mol

Synonyms:oct-3-ynoic acid

Chemical Property of oct-3-ynoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of oct-3-ynoic acid

There total 9 articles about oct-3-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

oct-3-yn-1-ol (14916-80-4) → oct-3-ynoic acid (57074-96-1)

Guidance literature:

With Jones reagent; In acetone; at 0 ℃; for 0.25h;

DOI:10.1039/c9cc01689a

Reference yield:

1-bromo-2-heptyne (18495-26-6) + carbon dioxide (124-38-9,18923-20-1) → oct-3-ynoic acid (57074-96-1) + 2-butyl-2,3-butadienoic acid (5665-73-6)

Guidance literature:

With lithium chloride; zinc; In 1,2-dimethoxyethane; at 20 ℃; for 24h; Reagent/catalyst; regioselective reaction; Schlenk technique; Glovebox; Cooling with liquid nitrogen;

DOI:10.1002/chem.201503494

Reference yield:

diethyl ether (60-29-7,927820-24-4) + 1-bromo-2-heptyne (18495-26-6) → oct-3-ynoic acid (57074-96-1) + 2-butyl-2,3-butadienoic acid (5665-73-6) + butyl-(2-butyl-1-methylene-buta-2,3-dienyl)-malonic acid (101448-54-8)

Guidance literature:

und anschliessend mit festem Kohlendioxid;

DOI:10.1021/jo01105a631 DOI:10.1021/jo01120a002 DOI:10.1021/ja01160a058

upstream raw materials:

1-bromo-2-heptyne

oct-3-yn-1-ol

methylammonium carbonate

diethyl ether

Downstream raw materials:

cis-3-octenoic acid

malonic acid

Octanoic acid

diethyl 2-(N-(benzyl)oct-3-ynamido)malonate

Refernces

• 1、 Fang, Weiwei,Breit, Bernhard. "Tandem Regioselective Hydroformylation-Hydrogenation of Internal Alkynes Using a Supramolecular Catalyst". supporting information. p. 14817 - 14821. Retrieved 2018/10/24.
• 2、 Wu, Yongwei,Singh, Ravi P.,Deng, Li. "Asymmetric olefin isomerization of butenolides via proton transfer catalysis by an organic molecule". supporting information; scheme or table. p. 12458 - 12461. Retrieved 2011/10/09.