(R)-1-(3,4-Dimethoxyphenyl)ethylamine

Base Information

• Chemical Name: (R)-1-(3,4-Dimethoxyphenyl)ethylamine
• CAS No.: 100570-24-9
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 29222990
• European Community (EC) Number: 663-068-6
• Mol file: 100570-24-9.mol

Synonyms:100570-24-9;(R)-1-(3,4-DIMETHOXYPHENYL)ETHYLAMINE;(R)-1-(3,4-dimethoxyphenyl)ethanamine;(1R)-1-(3,4-dimethoxyphenyl)ethanamine;(1R)-1-(3,4-dimethoxyphenyl)ethan-1-amine;(R)-3,4-Dimethoxy-alpha-methylbenzylamine;MFCD06761897;Benzenemethanamine, 3,4-dimethoxy-alpha-methyl-, (alphaR)-;SCHEMBL3976767;AKOS017343661;DS-12106;(R)-1-(3,4-dimethoxyphenyl)ethan-1-amine;CS-0000276;EN300-87775;(R)-1-(3,4-Dimethoxyphenyl)ethylamine, 95%;Y10474;A910831;Benzenemethanamine, 3,4-dimethoxy--methyl-, (R)-;(R)-3,4-Dimethoxy-alpha-methylbenzylamine, ChiPros(R), produced by BASF, 99%

Chemical Property of (R)-1-(3,4-Dimethoxyphenyl)ethylamine

Chemical Property:

• Vapor Pressure: 0.00623mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 272 °C at 760 mmHg
• PKA: 9.18±0.10(Predicted)
• Flash Point: 128.2 °C
• PSA: 44.48000
• Density: 1.037 g/cm³
• LogP: 2.42380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 181.110278721
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

98%min ^*data from raw suppliers

(R)-1-(3,4-Dimethoxyphenyl)ethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-38-41
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC(=C(C=C1)OC)OC)N
• Isomeric SMILES: C[C@H](C1=CC(=C(C=C1)OC)OC)N

Technology Process of (R)-1-(3,4-Dimethoxyphenyl)ethylamine

There total 6 articles about (R)-1-(3,4-Dimethoxyphenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

[(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine (293307-92-3) → 1,4-Dihydroxynaphthalene (571-60-8) + 1-(R)-(3,4-dimethoxyphenyl)ethylamine (100570-24-9)

Guidance literature:

[(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine; With ammonium cerium(IV) nitrate; In water; acetonitrile;

With sodium tetrahydroborate; In water; acetonitrile;

DOI:10.1016/S0040-4039(00)00830-3

Reference yield: 33.0%

acetic anhydride (108-24-7) + N-(4-methoxyphenyl)-1-(3,4-dimethoxyphenyl)ethylamine → benzene-1,4-diyl diacetate (1205-91-0) + 1-(R)-(3,4-dimethoxyphenyl)ethylamine (100570-24-9) + N-[1-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Guidance literature:

N-(4-methoxyphenyl)-1-(3,4-dimethoxyphenyl)ethylamine; With ammonium cerium(IV) nitrate; In water; acetonitrile;

With sodium tetrahydroborate; In water; acetonitrile;

acetic anhydride; With sodium carbonate; In water; acetonitrile;

DOI:10.1016/S0040-4039(00)00830-3

Reference yield: 32.0%

acetic anhydride (108-24-7) + [(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine (293307-92-3) → 1-(R)-(3,4-dimethoxyphenyl)ethylamine (100570-24-9) + N-[1-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Guidance literature:

[(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine; With ammonium cerium(IV) nitrate; In water; acetonitrile;

With sodium tetrahydroborate; In water; acetonitrile;

acetic anhydride; With sodium hydroxide; In water; acetonitrile;

DOI:10.1016/S0040-4039(00)00830-3

upstream raw materials:

acetic anhydride

[(R)-1-(3,4-Dimethoxy-phenyl)-ethyl]-(4-methoxy-naphthalen-1-yl)-amine

1-(3',4'-Dimethoxyphenyl)ethylamine

Downstream raw materials:

C₁₈H₁₇NO₅

N-(4-chloro-3-trifluoromethylphenyl)-2-[(R)-1-(3,4-dimethoxyphenyl)-ethylamino]-acetamide

Refernces

• 1、 -. "HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS". Page/Page column 44. . Retrieved 2008/06/13.