S-(-)-a-Methyl-p-aminobenzylamine

Base Information

• Chemical Name: S-(-)-a-Methyl-p-aminobenzylamine
• CAS No.: 65645-33-2
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Mol file: 65645-33-2.mol

Synonyms:Benzenemethanamine,4-amino-a-methyl-, (S)- (9CI);S-(-)-a-Methyl-p-aminobenzylamine;

Chemical Property of S-(-)-a-Methyl-p-aminobenzylamine

Chemical Property:

• Boiling Point: 269.73 °C at 760 mmHg
• Flash Point: 137.619 °C
• PSA: 52.04000
• Density: 1.056 g/cm³
• LogP: 2.57000

Purity/Quality:

99% ^*data from raw suppliers

(S)-4-(1-Amino-ethyl)-phenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of S-(-)-a-Methyl-p-aminobenzylamine

There total 12 articles about S-(-)-a-Methyl-p-aminobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-(-)-α-methyl-4-nitrobenzylamine hydrochloride (132873-57-5,92203-66-2) → 4-amino-(S)-α-methylbenzylamine (65645-33-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; for 6h; under 2068.65 Torr;

Reference yield: 62.0%

R-alpha-methyl-4-nitrobenzylamine hydrochloride (132873-57-5,92203-66-2) → 4-((R)-1-Amino-ethyl)-phenylamine (65645-32-1,65645-33-2)

Guidance literature:

With tin(II) chloride dihdyrate; In ethyl acetate; at 20 ℃;

Reference yield: 61.0%

p-chloro-(R,S)-1-phenylethylamine (35588-60-4) → 4-(1-aminoethyl)phenylamine (90434-58-5,65645-33-2)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 65 ℃; for 18h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201000526

upstream raw materials:

p-aminoacetophenone oxime

1-(4-nitro-phenyl)-ethylamine

(4-nitrophenyl)ethanone

p-chloro-(R,S)-1-phenylethylamine

Refernces

• 1、 -. "NOVEL CATALYSTS". Page/Page column 62. . Retrieved 2012/06/01.
• 2、 Guijarro, David,Pablo, Oscar,Yus, Miguel. "Asymmetric synthesis of chiral primary amines by transfer hydrogenation of N -(tert -Butanesulfinyl)ketimines". supporting information; experimental part. p. 5265 - 5270. Retrieved 2010/10/21.