3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate

Base Information

• Chemical Name: 3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate
• CAS No.: 454646-66-3
• Molecular Formula: C₁₅H₂₅N₃O₂
• Molecular Weight: 279.382
• Mol file: 454646-66-3.mol

Synonyms:3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate

Chemical Property of 3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate

There total 5 articles about 3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

c-hexylethyl isocyanate (76649-96-2) + 3-(1H-imidazol-4-yl)-propan-1-ol hydrochloride → 3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate (454646-66-3)

Guidance literature:

c-hexylethyl isocyanate; 3-(1H-imidazol-4-yl)-propan-1-ol hydrochloride; In acetonitrile; Reflux;

With ammonia; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2011.03.046

Reference yield:

cyclohexylethan-1-ol (4442-79-9) → 3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate (454646-66-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: pyrographite / ethyl acetate / Reflux

4: acetonitrile / Reflux

With pyrographite; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; ethyl acetate; acetonitrile; 1: Mitsunobu reaction;

DOI:10.1016/j.bmc.2011.03.046

Reference yield:

2-cyclohexylethan-1-amine hydrochloride (5471-55-6) → 3-(1H-imidazol-4-yl)propyl 2-cyclohexylethylcarbamate hydrogen maleate (454646-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyrographite / ethyl acetate / Reflux

2: acetonitrile / Reflux

With pyrographite; In ethyl acetate; acetonitrile;

DOI:10.1016/j.bmc.2011.03.046

upstream raw materials:

2-(2-cyclohexylethyl)isoindoline-1,3-dione

cyclohexylethan-1-ol

c-hexylethyl isocyanate

2-cyclohexylethan-1-amine hydrochloride

Refernces

• 1、 Wicek, Ma?gorzata,Kottke, Tim,Ligneau, Xavier,Schunack, Walter,Seifert, Roland,Stark, Holger,Handzlik, Jadwiga,Kie?-Kononowicz, Katarzyna. "N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands". . p. 2850 - 2858. Retrieved 2011/06/21.