2-bromo-1-(4-(4-methyl-1Himidazol-1-yl)phenyl)ethanone

Base Information

• Chemical Name: 2-bromo-1-(4-(4-methyl-1Himidazol-1-yl)phenyl)ethanone
• CAS No.: 810662-38-5
• Molecular Formula: C₁₂H₁₁BrN₂O
• Molecular Weight: 279.136
• Hs Code.: 2933290090
• Mol file: 810662-38-5.mol

Synonyms:2-Bromo-1-[4-(4-methyl-1H-imidazol-1-yl)phenyl]ethanone;2-Brom-1-[4-(4-methyl-1H-imidazol-1-yl)phenyl]ethanon;

Chemical Property of 2-bromo-1-(4-(4-methyl-1Himidazol-1-yl)phenyl)ethanone

Chemical Property:

• Boiling Point: 417.9 °C at 760 mmHg
• PKA: 5.47±0.61(Predicted)
• Flash Point: 206.6 °C
• PSA: 34.89000
• Density: 1.44 g/cm³
• LogP: 2.75830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-1-(4-(4-methyl-1h-imidazol-1-yl)phenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-1-(4-(4-methyl-1Himidazol-1-yl)phenyl)ethanone

There total 3 articles about 2-bromo-1-(4-(4-methyl-1Himidazol-1-yl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-(4-methylimidazol-1-yl)acetophenone (142161-53-3) → 2-bromo-1-[4-(4-methylimidazole-1-yl)phenyl]ethanone (810662-38-5)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 2h;

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 2-bromo-1-[4-(4-methylimidazole-1-yl)phenyl]ethanone (810662-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 18 h / 55 °C

2: hydrogen bromide; acetic acid; bromine / chloroform; ethyl acetate / 1.5 h / 25 °C

With hydrogen bromide; bromine; potassium carbonate; acetic acid; In chloroform; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.bmc.2020.115734

Reference yield:

4-acetylphenylboronic acid (149104-90-5) → 2-bromo-1-[4-(4-methylimidazole-1-yl)phenyl]ethanone (810662-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate; pyridine / N,N-dimethyl-formamide; dichloromethane / 16 h / 20 °C / Molecular sieve

2: hydrogen bromide; acetic acid / 2 h / 20 °C

With pyridine; hydrogen bromide; copper diacetate; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4'-(4-methylimidazol-1-yl)acetophenone

4-acetylphenylboronic acid

1-(4-fluorophenyl)ethanone

Downstream raw materials:

C₂₃H₂₄N₄OS

Refernces

• 1、 -. "COMPOUDS AND USES THEREOF IN MODULATING AMYLOID BETA". Paragraph 0166; 0168. . Retrieved 2015/11/16.