1-Boc-3-Ethylaminopiperidine

Base Information

• Chemical Name: 1-Boc-3-Ethylaminopiperidine
• CAS No.: 883546-56-3
• Molecular Formula: C₁₂H₂₄N₂O₂
• Molecular Weight: 228.335
• Hs Code.: 2933399090
• Mol file: 883546-56-3.mol

Synonyms:3-(Ethylamino)-1-piperidinecarboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-(ethylaMino)-, 1,1-diMethylethyl ester

Chemical Property of 1-Boc-3-Ethylaminopiperidine

Chemical Property:

• Vapor Pressure: 0.00079mmHg at 25°C
• Refractive Index: 1.484
• Boiling Point: 306.1 °C at 760 mmHg
• PKA: 10.24±0.20(Predicted)
• Flash Point: 138.9 °C
• PSA: 41.57000
• Density: 1 g/cm³
• LogP: 2.32420
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Boc-3-Ethylaminopiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-Ethylaminopiperidine

There total 2 articles about 1-Boc-3-Ethylaminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H22N2O2 → C12H24N2O2 (883546-56-3,1141893-10-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2016.09.030

Reference yield:

3-oxo-piperidine-1-carboxylic acid tert-butyl ester (98977-36-7) → C12H24N2O2 (883546-56-3,1141893-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol; tetrahydrofuran / 1 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / methanol; tetrahydrofuran / 15 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmc.2016.09.030

upstream raw materials:

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

Refernces