(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

Base Information

• Chemical Name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
• CAS No.: 477600-70-7
• Molecular Formula: C14H22 N2
• Molecular Weight: 218.342
• Hs Code.: 2933399090
• Mol file: 477600-70-7.mol

Synonyms:(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

Chemical Property of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

Chemical Property:

• Vapor Pressure: 0.000978mmHg at 25°C
• Boiling Point: 302.6°Cat760mmHg
• PKA: 10.26±0.40(Predicted)
• Flash Point: 107.4°C
• PSA: 15.27000
• Density: 1g/cm³
• LogP: 2.44520
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

(3R,?4R)?-N,?4-?Dimethyl-?1-?benzyl?-3-?piperidinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3R,?4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine (D464895) is a reagent used in the preparation of Janus tyrosine kinase inhibitors for the treatment of autoimmune diseases.

Technology Process of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

There total 37 articles about (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

1-benzyl-N,4-dimethyl-1,2,5,6-tetrahydropyridine-3-amine → N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine (477600-70-7,1354621-59-2,1431697-80-1,477600-69-4)

Guidance literature:

With R-(+)-1,1'-binaphthyl-2,2'-diphenylphosphine; ruthenium bis(acetate); hydrogen; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 12h; under 26252.6 Torr; Concentration; Solvent; Pressure; enantioselective reaction; Catalytic behavior;

Reference yield: 90.0%

(2R,3R)-2-methylamino-3-methyl-N-benzylglutarimide → N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine (477600-70-7,1354621-59-2,1431697-80-1,477600-69-4)

Guidance literature:

With zinc(II) tetrahydroborate; In tetrahydrofuran; at 30 ℃; for 2h; Inert atmosphere; Reflux;

Reference yield: 89.0%

bis[(1-benzyl-4-methylpiperidin-3-yl)methylamine] di-p-anisoyl-L-tartarate → N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine (477600-70-7,1354621-59-2,1431697-80-1,477600-69-4)

Guidance literature:

With potassium carbonate; In water; ethyl acetate; for 0.5h; Reflux;

upstream raw materials:

(1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamic acid methyl ester

1-benzyl-3-methoxycarbonylamino-4-methyl-pyridinium bromide

tert-butyl (3R,4R)-1-benzyl-4-methylpiperidin-3-ylcarbamate

benzylamine

Downstream raw materials:

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7-p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Refernces

• 1、 -. "Preparation methods of tofacitinib intermediate amine and dihydrochloride thereof". Paragraph 0025; 0089-0090. . Retrieved 2020/11/12.
• 2、 -. "PROCESS FOR PREPARING CHIRAL AMINES". Page/Page column 14; 15. . Retrieved 2018/04/17.