Dibenzyl chlorophosphonate

Base Information

• Chemical Name: Dibenzyl chlorophosphonate
• CAS No.: 538-37-4
• Molecular Formula: C14H14ClO3P
• Molecular Weight: 296.69
• Hs Code.: 2931900090
• European Community (EC) Number: 633-393-8
• UNII: JWP897QDQL
• Nikkaji Number: J6.370C
• Wikidata: Q27281727
• Mol file: 538-37-4.mol

Synonyms:538-37-4;Dibenzyl chlorophosphonate;DIBENZYL PHOSPHOROCHLORIDATE;DBPCL;Dibenzyl chlorophosphonate [MI];Phosphorochloridic acid, bis(phenylmethyl) ester;UNII-JWP897QDQL;JWP897QDQL;Dibenzyl chlorophosphate;[chloro(phenylmethoxy)phosphoryl]oxymethylbenzene;MFCD01074633;Dibenzylphosphoryl chloride (10% w/w in toluene);Dibenzylphosphoryl Chloride, [95per cent], in benzene - ~10per cent w/v;dibenzylphosphorochloridate;SCHEMBL85540;YADJFRGSGWGMNH-UHFFFAOYSA-N;AKOS028111760;Dibenzylphosphoryl chloride, in benzene;SY270141;Chlorophosphoric Acid Dibenzyl Ester Solution;FT-0600224;EN300-109512;F16277;Q27281727;Dibenzylphosphoryl Chloride, [95%], in benzene - ~10% w/v

Chemical Property of Dibenzyl chlorophosphonate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 428.2 °C at 760 mmHg
• Flash Point: 339.9 °C
• PSA: 45.34000
• Density: 1.283 g/cm³
• LogP: 4.76690
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 296.0369090
• Heavy Atom Count: 19
• Complexity: 273

Purity/Quality:

99% ^*data from raw suppliers

DibenzylphosphorylChloride,[95%],inbenzene-~10%w/v ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COP(=O)(OCC2=CC=CC=C2)Cl
• Uses: In solutions with inert solvents such as chloroform, carbon tetrachloride, benzene and ether for the phosphorylation of nucleosides and amino acids. Please note that this product is shipped in a cooler

Technology Process of Dibenzyl chlorophosphonate

There total 16 articles about Dibenzyl chlorophosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Dibenzyl phosphite (17176-77-1) → dibenzyl phosphochloridate (538-37-4)

Guidance literature:

With N-chloro-succinimide; In toluene; at 20 ℃; for 2.5h;

Reference yield: 95.0%

dibenzyl hydrogen phosphite (538-60-3) → dibenzyl phosphochloridate (538-37-4)

Guidance literature:

With N-chloro-succinimide; In toluene; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 84.0%

trifluoroacetate salt of glycyl-L-proline amide + dibenzyl hydrogen phosphite (538-60-3) → Nα-(dibenzylphosphoryl)-glycyl-L-proline amide + dibenzyl phosphochloridate (538-37-4)

Guidance literature:

With triethylamine;

upstream raw materials:

N-chloro-succinimide

Dibenzyl phosphite

dibenzyl hydrogen phosphite

tribenzylphosphate

Downstream raw materials:

adenosine monophosphate

adenosine 2'-monophosphate

phosphoric acid dibenzyl ester

(+/-)-phosphoric acid dibenzyl ester-(cis-2-hydroxy-cyclohexyl ester)

Refernces

• 1、 Li, Shunlai,Zhou, Cheng,Yu, Mingwu,He, Qiwen,Du, Hongguang. "Synthesis, anti-platelet aggregation activity evaluation and structure–activity relationships of a series of novel purine derivatives". . p. 2889 - 2903. Retrieved 2020.
• 2、 De Villiers, Marianne,Spry, Christina,Macuamule, Cristiano J.,Barnard, Leanne,Wells, Gordon,Saliba, Kevin J.,Strauss, Erick. "Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target". . p. 527 - 541. Retrieved 2017.
• 3、 -. "PANTETHEINE DERIVATIVES AND USES THEREOF". Paragraph 2121. . Retrieved 2020/06/19.
• 4、 -. "Heterocyclic amide compound, pharmaceutical composition containing heterocyclic amide compound, preparation method of heterocyclic amide compound and application of heterocyclic amide compound". Paragraph 0311-0314. . Retrieved 2020/04/17.