7-Phenyl-3,5,7-trioxoheptansaeuremethylester

Base Information

• Chemical Name: 7-Phenyl-3,5,7-trioxoheptansaeuremethylester
• CAS No.: 15148-46-6
• Molecular Formula: C₁₄H₁₄O₅
• Molecular Weight: 262.262
• Mol file: 15148-46-6.mol

Synonyms:7-Phenyl-3,5,7-trioxoheptansaeuremethylester

Chemical Property of 7-Phenyl-3,5,7-trioxoheptansaeuremethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Phenyl-3,5,7-trioxoheptansaeuremethylester

There total 6 articles about 7-Phenyl-3,5,7-trioxoheptansaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenylhexane-1,3,5-trione (1469-95-0) → 7-Phenyl-3,5,7-trioxoheptansaeuremethylester (15148-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaNH₂, liq. NH₃, Et₂O, (ii) /BRN= 1900390/

2: diethyl ether

In diethyl ether;

DOI:10.1021/ja01001a060

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 7-Phenyl-3.5.7-trioxo-heptansaeure (4809-02-3) → 7-Phenyl-3,5,7-trioxoheptansaeuremethylester (15148-46-6)

Guidance literature:

In diethyl ether;

DOI:10.1021/ja01001a060

Reference yield:

lithium salt of dimethyl malonate (74826-01-0) + dilithio 1-phenyl-1,3-butanedione → 7-Phenyl-3,5,7-trioxoheptansaeuremethylester (15148-46-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; Heating;

upstream raw materials:

diazomethane

7-Phenyl-3.5.7-trioxo-heptansaeure

benzoic acid methyl ester

3,5-dioxohexanoic acid methyl ester

Downstream raw materials:

2-benzoylphloroglucinol

Refernces

• 1、 Harris et al.. "". . p. 177. Retrieved 1969.
• 2、 Hill, James E.,Harris, Thomas M.. "ACYLATIONS OF β-DIKETONES WITH DIMETHYL MALONATE TO GIVE 3,5,7-TRIKOTO ESTERS AND THEIR CYCLIZATION PRODUCTS". . p. 621 - 626. Retrieved 2007/10/02.