1-(bromoethynyl)-4-chlorobenzene

Base Information

• Chemical Name: 1-(bromoethynyl)-4-chlorobenzene
• CAS No.: 33491-03-1
• Molecular Formula: C₈H₄BrCl
• Molecular Weight: 215.477
• Mol file: 33491-03-1.mol

Synonyms:1-(bromoethynyl)-4-chlorobenzene

Chemical Property of 1-(bromoethynyl)-4-chlorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(bromoethynyl)-4-chlorobenzene

There total 14 articles about 1-(bromoethynyl)-4-chlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-n-chlorophenylacetylene (873-73-4) → 1-(bromoethynyl)-4-chlorobenzene (33491-03-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; tetrabutylammomium bromide; In acetonitrile; at 20 ℃;

Reference yield: 98.0%

1-chloro-4-(2,2-dibromovinyl)benzene (77295-59-1) → 1-(bromoethynyl)-4-chlorobenzene (33491-03-1)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide; In dichloromethane; water; at 0 ℃; for 5h;

DOI:10.1021/ol5016898

Reference yield: 96.0%

(4-chlorophenyl)propiolic acid (3240-10-6) → 1-(bromoethynyl)-4-chlorobenzene (33491-03-1)

Guidance literature:

With N-Bromosuccinimide; tetrabutylammonium trifluoroacetate; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1021/jo990434g

upstream raw materials:

4-n-chlorophenylacetylene

1-ethynyl-4-chloro-benzene; mercury (II)-compound

-triphenyl-phosphoran

1-chloro-4-(2,2-dibromovinyl)benzene

Downstream raw materials:

5-(p-Chlorphenyl)-penta-2,4-diinal-diethylacetal

(p-Chlorphenyl)-aethinyl-p-methylphenyl-sulfid

5--pentadiin-(2.4)-saeure

4-n-chlorophenylacetylene

Refernces

• 1、 Xu, Hailong,Chen, Rui,Ruan, Hongjie,Ye, Ruyi,Meng, Ling-Guo. "Visible-Light-Promoted Formation of C—C and C—P Bonds Derived from Evolution of Bromoalkynes under Additive-Free Conditions: Synthesis of 1,1-Dibromo-1-en-3-ynes and Alkynylphosphine Oxides". supporting information. p. 873 - 878. Retrieved 2021/03/04.
• 2、 Yao, Liangliang,Hu, Qiong,Bao, Li,Zhu, Wenjing,Hu, Yimin. "Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone". supporting information. p. 4971 - 4975. Retrieved 2021/06/30.