2,5-Dimethoxyphenol

Base Information

• Chemical Name: 2,5-Dimethoxyphenol
• CAS No.: 18113-18-3
• Molecular Formula: C8H10O3
• Molecular Weight: 154.166
• Hs Code.: 2909500000
• European Community (EC) Number: 841-897-6
• DSSTox Substance ID: DTXSID50415660
• Nikkaji Number: J588.628G
• Wikidata: Q82224621
• Mol file: 18113-18-3.mol

Synonyms:2,5-Dimethoxyphenol;18113-18-3;Phenol, 2,5-dimethoxy-;2,5-DIMETHOXY-PHENOL;MFCD00094237;ghl.PD_Mitscher_leg0.593;Phenol,2,5-dimethoxy-;SCHEMBL581508;DTXSID50415660;CHEBI:183271;KYFBKHRLIHDKPB-UHFFFAOYSA-N;AKOS006275719;AM82858;CS-W023061;GS-4032;MB00643;SY035119;D5666;FT-0691457;EN300-107099;A881018

Chemical Property of 2,5-Dimethoxyphenol

Chemical Property:

• Vapor Pressure: 0.0044mmHg at 25°C
• Refractive Index: 1.522
• Boiling Point: 269.4 °C at 760 mmHg
• PKA: 9.59±0.10(Predicted)
• Flash Point: 116.7 °C
• PSA: 38.69000
• Density: 1.134 g/cm³
• LogP: 1.40940
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 154.062994177
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

99%, ^*data from raw suppliers

2,5-Dimethoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC)O

Technology Process of 2,5-Dimethoxyphenol

There total 27 articles about 2,5-Dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,5-dimethoxybenzaldehyde (93-02-7) → 2,5-dimethoxyphenol (18113-18-3)

Guidance literature:

With bis(2-phenyltrifluoromethanesulfonate)diselenide; dihydrogen peroxide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2005.10.055

Reference yield: 98.0%

2,5-dimethoxyphenyl acetate (27257-06-3) → 2,5-dimethoxyphenol (18113-18-3)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 70 ℃; for 0.5h;

DOI:10.1002/ejoc.201200176

Reference yield: 95.0%

4-Methoxybenzenethiol (696-63-9) + 1,2,4-trimethoxy-benzene (135-77-3) → 2,5-dimethoxyphenol (18113-18-3)

Guidance literature:

With sodium; In N,N-dimethyl acetamide; at 100 ℃; for 4h;

DOI:10.1055/s-1983-30501

upstream raw materials:

2,5-dimethoxyphenyl acetate

diethyl ether

phenyllithium

1,4-dimethoxybezene

Downstream raw materials:

3-(2,5-dimethoxy-phenoxy)-propionic acid

2,5-dimethoxyquinone

3,5-dinitro-benzoic acid-(2,5-dimethoxy-phenyl ester)

1,4-dimethoxy-2-((2-methylbut-3-yn-2-yl)oxy)benzene

Refernces

• 1、 George, Josemon,Ward, Jas S.,Sherburn, Michael S.. "Diene-Transmissive Diels-Alder Sequences with Benzynes". . p. 7529 - 7533. Retrieved 2019.
• 2、 Lorenz, Peter,Heller, Annerose,Bunse, Marek,Heinrich, Miriam,Berger, Melanie,Conrad, Jürgen,Stintzing, Florian C.,Kammerer, Dietmar R.. "Structure Elucidation of the Main Tetrahydroxyxanthones of Hypericum Seeds and Investigations into the Testa Structure". . . Retrieved 2018/05/14.