2-Amino-alpha-(Methoxyimino)-4-Thiazoleacetic Acid

Base Information

• Chemical Name: 2-Amino-alpha-(Methoxyimino)-4-Thiazoleacetic Acid
• CAS No.: 91868-79-0
• Molecular Formula: C6H7 N3 O3 S
• Molecular Weight: 201.206
• Mol file: 91868-79-0.mol

Synonyms:SQ28756

Chemical Property of 2-Amino-alpha-(Methoxyimino)-4-Thiazoleacetic Acid

Chemical Property:

• PSA: 143.84000
• LogP: 0.00720

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-alpha-(Methoxyimino)-4-Thiazoleacetic Acid

There total 1 articles about 2-Amino-alpha-(Methoxyimino)-4-Thiazoleacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cefotaxime (758680-79-4,152186-43-1) → 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid (91868-79-0) + desacetoxycefotaxime (65052-63-3) + desacetylcefotaxime (66340-28-1,121020-94-8,74440-61-2,99124-78-4) + desacetylcefotaxime lactone (66340-33-8) + 7-aminocephalosporanic acid (108260-00-0)

Guidance literature:

With bromine; In methanol; water; at 20 ℃; Product distribution; number "n" of bromine molecules consumed by one molecule of the compound;;

DOI:10.1021/ac00153a008

Reference yield: 99.0%

2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid (91868-79-0) + C18H18N2O3 → methyl (3’S*,4’R*)-2-{3-[2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-2-oxo-4-phenylazetidin-1-yl}-2-phenylacetate

Guidance literature:

With 4-methyl-morpholine; O‐(1H‐benzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/asia.201901470

Reference yield: 97.0%

2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid (91868-79-0) + di(benzothiazol-2-yl)disulfide (120-78-5) → 2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one (94088-75-2)

Guidance literature:

With pyridine; triethylamine; triethyl phosphite; In dichloromethane; acetonitrile; at 16.5 - 23 ℃; for 2h; Temperature; Reagent/catalyst;

upstream raw materials:

cefotaxime

Downstream raw materials:

7-<<(2-Amino4-thiazolyl)(methoxyimino)acetyl>amino>-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester

cefepime sulfate

C₁₉H₁₇Cl₂N₃O₆S

2-(2-tritylamino-thiazol-4-yl)-(Z)-2-methoxyiminoacetic acid

Refernces