6-Chloro-2(1H)-quinoxalinone

Base Information

• Chemical Name: 6-Chloro-2(1H)-quinoxalinone
• CAS No.: 2427-71-6
• Deprecated CAS: 39267-06-6
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.593
• Hs Code.: 2933990090
• European Community (EC) Number: 813-002-9
• DSSTox Substance ID: DTXSID7062409
• Nikkaji Number: J43.020J
• Wikidata: Q72483498
• Mol file: 2427-71-6.mol

Synonyms:2427-71-6;6-CHLORO-2(1H)-QUINOXALINONE;2-Hydroxy-6-chloroquinoxaline;6-chloroquinoxalin-2-ol;6-chloro-1H-quinoxalin-2-one;6-Chloro-2-hydroxyquinoxaline;2(1H)-Quinoxalinone, 6-chloro-;6-Chloroquinoxalin-2(1H)-one;39267-06-6;C8H5ClN2O;6-chloro-1,2-dihydroquinoxalin-2-one;6-chloro-2-quinoxalinol;SCHEMBL7757513;SCHEMBL8530324;DTXSID7062409;MFCD03265373;Hydroxy quinoxaline (CGA 290291);AKOS006229832;AKOS015850358;DS-0252;FS-3222;GS-3398;AC-11450;AM20070334;FT-0612565;EN300-306612;S10160;A817187;J-015429;J-518507;Z1198166471;6-Chloro-2(1H)-quinoxalinone

Chemical Property of 6-Chloro-2(1H)-quinoxalinone

Chemical Property:

• Appearance/Colour: Crystalline Powder
• Vapor Pressure: 7.46E-07mmHg at 25°C
• Melting Point: 305 °C
• Refractive Index: 1.688
• Boiling Point: 396.5 °C at 760 mmHg
• PKA: 8.10±0.70(Predicted)
• Flash Point: 193.6 °C
• PSA: 46.01000
• Density: 1.5 g/cm³
• LogP: 1.98880
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 180.0090405
• Heavy Atom Count: 12
• Complexity: 229

Purity/Quality:

2-Hydroxy-6-chloroquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1Cl)N=CC(=O)N2
• Uses: Intermediate for the production of herbicides. Attributes PIS available, please contact us Contact

Technology Process of 6-Chloro-2(1H)-quinoxalinone

There total 5 articles about 6-Chloro-2(1H)-quinoxalinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

6-chloro-1,2-dihydro-2-oxoquinoxaline 4-oxide (34836-97-0) → quinoxalin-2(1)-one (1196-57-2) + 6-chloro-1,2-dihydroquinoxalin-2-one (2427-71-6) + 6-chloro-1,2,3,4-tetrahydroquinoxalin-2-one (89938-22-7) + 6-chloro-3-hydroxy-2(1H)-quinoxalinone (6639-79-8)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; for 1.5h; Product distribution; Ambient temperature; other reducing agents;

Reference yield: 93.8%

6-chloro-1,2-dihydro-2-oxoquinoxaline 4-oxide (34836-97-0) → 6-chloro-1,2-dihydroquinoxalin-2-one (2427-71-6) + 6-chloro-1,2,3,4-tetrahydroquinoxalin-2-one (89938-22-7)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; for 1.5h; Ambient temperature;

Reference yield: 89.6%

4-Chloro-1,2-phenylenediamine (95-83-0) → 2-hydroxy-6-chloroquinoxaline (2427-71-6) + 7-chloroquinoxalin-2-ol (59489-30-4)

Guidance literature:

In isopropyl alcohol;

upstream raw materials:

6-chloro-1,2-dihydro-2-oxoquinoxaline 4-oxide

glyoxylic acid ethyl ester

4-Chloro-1,2-phenylenediamine

Refernces

• 1、 -. "(2-quinoxalinyloxy) phenoxypropanoic acids and related derivatives as anticancer agents". . . Retrieved 2008/06/13.