2-IODOBENZENE-1-SULFONYL CHLORIDE

Base Information

• Chemical Name: 2-IODOBENZENE-1-SULFONYL CHLORIDE
• CAS No.: 63059-29-0
• Molecular Formula: C6H4 Cl I O2 S
• Molecular Weight: 302.52
• Hs Code.: 2904909090
• Mol file: 63059-29-0.mol

Synonyms:2-Iodobenzenesulfonylchloride; o-Iodobenzenesulfonyl chloride

Chemical Property of 2-IODOBENZENE-1-SULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.000338mmHg at 25°C
• Melting Point: 51 °C
• Boiling Point: 329.5°C at 760 mmHg
• Flash Point: 153.1°C
• PSA: 42.52000
• Density: 2.041
• LogP: 3.29950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Iodobenzenesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Iodobenzenesulfonyl Chloride can be used as phosphoglycerate mutase 1 inhibitors as a promising target for cancer therapy.

Technology Process of 2-IODOBENZENE-1-SULFONYL CHLORIDE

There total 6 articles about 2-IODOBENZENE-1-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-iodobenzenesulfonic acid (63059-25-6) → 2-iodobenzene-1-sulfonyl chloride (63059-29-0)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; In neat (no solvent); at 120 ℃;

DOI:10.1002/anie.202013275

Reference yield:

2-amino-1-benzenesulfonic acid (88-21-1) → 2-iodobenzene-1-sulfonyl chloride (63059-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Na₂CO₃; NaNO₂; HCl / H₂O / 0 - 25 °C

1.2: potassium iodide / H₂O / Heating

2.1: PCl₅

With hydrogenchloride; phosphorus pentachloride; sodium carbonate; sodium nitrite; In water;

DOI:10.1016/j.bmc.2006.03.050

Reference yield:

potassium 2-iodobenzenesulfonate → 2-iodobenzene-1-sulfonyl chloride (63059-29-0)

Guidance literature:

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1021/jo061125a

upstream raw materials:

2-iodobenzenesulfonic acid

2-amino-1-benzenesulfonic acid

(2-iodophenyl)ethylxanthate

Downstream raw materials:

2-iodobenzene-sulfonamide

2-(5-cyano-pent-1-ynyl)-4,N-dimethyl-benzenesulfonamide

2-hydroxymethyl-1-(2-iodophenylsulfonyl)piperidine

Refernces

• 1、 Li, Jun,Shi, Hongwei,Zhang, Shan,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.. "Switchable Divergent Synthesis in Gold-Catalyzed Difunctionalizations of o-Alkynylbenzenesulfonamides with Aryldiazonium Salts". supporting information. p. 7713 - 7717. Retrieved 2021/10/20.
• 2、 Barbero, Margherita,Bazzi, Stefano,Cadamuro, Silvano,Dughera, Stefano,Magistris, Claudio,Venturello, Paolo. "A new effective synthesis of arene mono- and disulfonyl chlorides". supporting information; experimental part. p. 1803 - 1806. Retrieved 2010/10/20.