2-METHOXY-4-METHYLBENZOIC ACID

Base Information

• Chemical Name: 2-METHOXY-4-METHYLBENZOIC ACID
• CAS No.: 704-45-0
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2918990090
• Mol file: 704-45-0.mol

Synonyms:o-Anisicacid, 4-methyl- (6CI,7CI);2-Methoxy-4-methylbenzoic acid;4-Methyl-2-methoxybenzoic acid;

Chemical Property of 2-METHOXY-4-METHYLBENZOIC ACID

Chemical Property:

• Vapor Pressure: 0.00029mmHg at 25°C
• Melting Point: 103-107 °C(lit.)
• Refractive Index: 1.54
• Boiling Point: 308.7 °C at 760 mmHg
• PKA: 4.26±0.10(Predicted)
• Flash Point: 125.6 °C
• PSA: 46.53000
• Density: 1.168g/cm³
• LogP: 1.70180
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxy-4-methylbenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn; Xi
• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-4-METHYLBENZOIC ACID

There total 23 articles about 2-METHOXY-4-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-hydroxy-p-toluic acid (50-85-1) + methyl iodide (74-88-4) → 2-methoxy-4-methylbenzoic acid (704-45-0)

Guidance literature:

2-hydroxy-p-toluic acid; methyl iodide; With potassium carbonate; In acetone; at 65 ℃; Inert atmosphere; Schlenk technique;

With sodium hydroxide; In water; at 100 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c02127

Reference yield: 99.0%

2-methoxy-4-methylbenzaldehyde (57415-35-7) → 2-methoxy-4-methylbenzoic acid (704-45-0)

Guidance literature:

With sodium chlorite; aminosulfonic acid; In tetrahydrofuran; water; Ambient temperature;

DOI:10.1055/s-1987-28061

Reference yield: 98.0%

methyl 4-methyl-2-methoxybenzoate (81245-24-1) → 2-methoxy-4-methylbenzoic acid (704-45-0)

Guidance literature:

With water; sodium hydroxide; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.151004

upstream raw materials:

methyl 4-methyl-2-methoxybenzoate

2-hydroxy-p-toluic acid

dimethyl sulfate

Anhydroitaconitin-methylether

Downstream raw materials:

2-(2-Methoxy-4-methyl-phenyl)-3H-imidazo[4,5-c]pyridine; hydrochloride

2-methoxyterephthalic acid

(E)-2-methoxy-4-methyl-β-nitrostyrene

4-(Bromomethyl)-N-tert-butyl-2-methoxybenzamide

Refernces

• 1、 -. "Preparation method and application of 4-hydroxyemodin". Paragraph 0048; 0052-0053. . Retrieved 2020/04/29.
• 2、 Yang, Wen,Zhang, Wu,Zhao, Wanxiang. "Lewis acid-promoted site-selective cyanation of phenols". . p. 4604 - 4609. Retrieved 2020/07/04.