2-Methoxy-5-fluoro-4-aminopyrimidine

Base Information

• Chemical Name: 2-Methoxy-5-fluoro-4-aminopyrimidine
• CAS No.: 1993-63-1
• Molecular Formula: C5H6FN3O
• Molecular Weight: 143.121
• Hs Code.: 2933599090
• Mol file: 1993-63-1.mol

Synonyms:Pyrimidine, 4-amino-5-fluoro-2-methoxy-;

Chemical Property of 2-Methoxy-5-fluoro-4-aminopyrimidine

Chemical Property:

• Melting Point: 193 °C
• Boiling Point: 278.863 °C at 760 mmHg
• PKA: 3.63±0.10(Predicted)
• Flash Point: 122.452 °C
• PSA: 61.03000
• Density: 1.345 g/cm³
• LogP: 0.78770
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluoro-2-methoxypyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-5-fluoro-4-aminopyrimidine

There total 5 articles about 2-Methoxy-5-fluoro-4-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methoxy-4-chloro-5-fluoropyrimidine (1801-06-5) → 4-amino-5-fluoro-2-methoxypyrimidine (1993-63-1)

Guidance literature:

With ammonia; In isopropyl alcohol; at 40 - 60 ℃;

Reference yield: 67.0%

O-methylisourea hydrosulfate (24285-39-0) + potassium (Z)-2-cyano-2-fluoroethenolate → 4-amino-5-fluoro-2-methoxypyrimidine (1993-63-1)

Guidance literature:

In methanol; at 20 ℃; for 14h; Inert atmosphere; Schlenk technique;

DOI:10.3762/bjoc.16.41

Reference yield: 41.0%

potassium (Z)-2-cyano-2-fluoroethenolate + O-methylisourea hemisulfate (52328-05-9,24285-39-0) → 4-amino-5-fluoro-2-methoxypyrimidine (1993-63-1)

Guidance literature:

In methanol; water; at 20 ℃; for 23h; Schlenk technique;

DOI:10.1002/ejoc.201900629

upstream raw materials:

2-methoxy-4-chloro-5-fluoropyrimidine

O-methylisourea hemisulfate

O-methylisourea hydrosulfate

Downstream raw materials:

Flucytosine

Refernces

• 1、 -. "Preparation method of 5- flucytosine". Paragraph 0029; 0034; 0037; 0042; 0045; 0050; 0053; 0058. . Retrieved 2019/12/25.
• 2、 -. "Method for 5-fluorocytosine". Paragraph 0038; 0039; 0040. . Retrieved 2016/11/17.