Baicalin methyl ester

Base Information

• Chemical Name: Baicalin methyl ester
• CAS No.: 82475-03-4
• Molecular Formula: C₂₂H₂₀O₁₁
• Molecular Weight: 460.394
• Mol file: 82475-03-4.mol

Synonyms:Baicalin methyl ester

Chemical Property of Baicalin methyl ester

Chemical Property:

• Melting Point: 268-270 °C
• Boiling Point: 754.5±60.0 °C(Predicted)
• PKA: 5.90±0.40(Predicted)
• Density: 1.631±0.06 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

Baicalinmethylester ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Baicalin methyl ester

There total 2 articles about Baicalin methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

chlorosulfite de methyle (13165-72-5) + baicalin (21967-41-9,27462-75-5,31564-28-0) → Baicalin methyl ester (82475-03-4)

Guidance literature:

In methanol; at 20 ℃; for 8.5h; Inert atmosphere;

DOI:10.1016/j.tet.2017.02.039

Reference yield: 95.0%

methanol (67-56-1) + baicalin (21967-41-9,27462-75-5,31564-28-0) → Baicalin methyl ester (82475-03-4)

Guidance literature:

With sulfuric acid; for 1h; Heating;

DOI:10.1016/j.bmc.2008.06.055

Reference yield: 97.0%

Baicalin methyl ester (82475-03-4) → 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one (491-67-8)

Guidance literature:

With sulfuric acid; In ethanol; water; at 95 ℃; for 8.5h; Inert atmosphere;

DOI:10.1016/j.tet.2017.02.039

upstream raw materials:

methanol

baicalin

chlorosulfite de methyle

Downstream raw materials:

Oroxin A

5,6-dihydroxy-7-methoxyflavone

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

5-hydroxy-6-methoxyflavone-7-O-β-D-glucuronide methyl ester

Refernces

• 1、 -. "PROCESS FOR SYNTHESIS OF OROXYLIN A". Page/Page column 7; 14. . Retrieved 2020/03/02.
• 2、 -. "Process for synthesis of Oroxylin A". Page/Page column 4; 13. . Retrieved 2019/09/23.