4,4'-DIETHOXYBIPHENYL

Base Information

• Chemical Name: 4,4'-DIETHOXYBIPHENYL
• CAS No.: 7168-54-9
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• Hs Code.: 2909309090
• Mol file: 7168-54-9.mol

Synonyms:Biphenyl,4,4'-diethoxy- (7CI,8CI);4,4'-Diethoxybiphenyl;

Chemical Property of 4,4'-DIETHOXYBIPHENYL

Chemical Property:

• Melting Point: 176 °C
• Boiling Point: 366.7 °C at 760 mmHg
• Flash Point: 143.1 °C
• PSA: 18.46000
• Density: 1.027 g/cm³
• LogP: 4.15100

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,4''-Diethoxybiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-DIETHOXYBIPHENYL

There total 32 articles about 4,4'-DIETHOXYBIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,5-dibromo benzo[b]furan + tris-(4-ethoxy-phenyl)-bismuthine (90591-48-3) → 4,4'-diethoxybiphenyl (7168-54-9) + 5-bromo-2-(4-ethoxyphenyl)benzofuran (1374787-42-4)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.03.059

Reference yield: 88.0%

5,7-dichloro-2-bromobenzo[b]furan (1336808-79-7) + tris-(4-ethoxy-phenyl)-bismuthine (90591-48-3) → 4,4'-diethoxybiphenyl (7168-54-9) + 5,7-dichloro-2-(4-ethoxyphenyl)benzofuran (1374787-39-9)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.03.059

Reference yield: 87.0%

4-chloro-6-methyl-2H-chromen-2-one (51069-75-1) + tris-(4-ethoxy-phenyl)-bismuthine (90591-48-3) → 4,4'-diethoxybiphenyl (7168-54-9) + 4-(4-ethoxyphenyl)-6-methyl-2H-chromen-2-one

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In N,N-dimethyl acetamide; at 90 ℃; for 2h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2014.07.059

upstream raw materials:

1-ethoxy-4-iodobenzene

ethyldifluorophenylsilane

bis(4-ethoxyphenyl) methylphosphonate

bis(4-ethoxyphenyl) ethyl phosphate

Refernces

• 1、 Tran, Huy,McCallum, Terry,Morin, Mathieu,Barriault, Louis. "Homocoupling of iodoarenes and bromoalkanes using photoredox gold catalysis: A light enabled Au(III) reductive elimination". supporting information. p. 4308 - 4311. Retrieved 2016/09/09.
• 2、 Rao, Maddali L.N.,Kumar, Abhijeet. "Pd-catalyzed cross-coupling study of bi-functional 3-bromo-4-trifloxycoumarins with triarylbismuth reagents". . p. 5137 - 5147. Retrieved 2015/06/30.