4-Carboxy-2-fluorobenzeneboronic acid

Base Information

• Chemical Name: 4-Carboxy-2-fluorobenzeneboronic acid
• CAS No.: 851335-07-4
• Molecular Formula: C7H6BFO4
• Molecular Weight: 183.932
• Hs Code.: 2931900090
• Mol file: 851335-07-4.mol

Synonyms:4-Carboxy-2-fluorobenzeneboronic acid;Benzoic acid, 4-borono-3-fluoro-;3,4-Difluorobenzophenone;4-Borono-3-fluorobenzoic acid;

Chemical Property of 4-Carboxy-2-fluorobenzeneboronic acid

Chemical Property:

• Boiling Point: 402.6 °C at 760 mmHg
• PKA: 3.74±0.10(Predicted)
• Flash Point: 197.3 °C
• PSA: 77.76000
• Density: 1.49 g/cm³
• LogP: -0.79630
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Carboxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 4-Carboxy-2-fluorobenzeneboronic acid

There total 2 articles about 4-Carboxy-2-fluorobenzeneboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-fluoro-4-formylphenyl)boronic acid (871126-22-6) → 2-fluoro 4-carboxy phenylboronic acid (851335-07-4)

Guidance literature:

With potassium permanganate;

DOI:10.1016/j.tet.2010.11.062

Reference yield:

→ 2-fluoro 4-carboxy phenylboronic acid (851335-07-4)

Guidance literature:

Reference yield: 98.0%

2,3-dimethyl-2,3-butane diol (76-09-5) + 2-fluoro 4-carboxy phenylboronic acid (851335-07-4) → 2-(4'-carboxy-2'-fluorophenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (1050423-87-4)

Guidance literature:

With magnesium sulfate; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

(2-fluoro-4-formylphenyl)boronic acid

Downstream raw materials:

4-(5-bromopyridin-2-yl)-3-fluorobenzoic acid

{4-[(4-{3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-1-yl}piperidin-1-yl)carbonyl]-2-fluorophenyl}boronic acid

3-fluoro-4-(7-methoxyisoquinolin-3-yl)benzoic acid

3-fluoro-4-(7-hydroxyisoquinolin-3-yl)benzoic acid

Refernces

• 1、 -. "AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE". Page/Page column 36. . Retrieved 2008/06/13.