5-METHYLBENZOFURAZAN

Base Information

• Chemical Name: 5-METHYLBENZOFURAZAN
• CAS No.: 20304-86-3
• Molecular Formula: C7H6 N2 O
• Molecular Weight: 134.137
• Hs Code.: 2934999090
• Mol file: 20304-86-3.mol

Synonyms:Benzofurazan,5-methyl- (6CI,8CI); 5-Methyl-2,1,3-Benzoxadiazole; 5-Methylbenzfurazan;5-Methylbenzofurazan

Chemical Property of 5-METHYLBENZOFURAZAN

Chemical Property:

• Vapor Pressure: 0.297mmHg at 25°C
• Melting Point: 33-35oC
• Boiling Point: 209.2°C at 760 mmHg
• Flash Point: 82°C
• PSA: 38.92000
• Density: 1.229g/cm³
• LogP: 1.53120

Purity/Quality:

99% ^*data from raw suppliers

5-Methyl-2,1,3-benzoxadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYLBENZOFURAZAN

There total 15 articles about 5-METHYLBENZOFURAZAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-methylbenzofuroxan (3524-05-8) → 5-methyl-benzo[1,2,5]oxadiazole (20304-86-3)

Guidance literature:

With sulfur; sodium hydroxide; In methanol; water; at 80 ℃; for 5h; Green chemistry;

DOI:10.1002/ejoc.202000064

Reference yield: 88.0%

5?(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[c][1,2,5]oxadiazole (1073355-14-2) + methyl iodide (74-88-4) → 5-methyl-benzo[1,2,5]oxadiazole (20304-86-3)

Guidance literature:

With C₂₁H₃₀ClNPPd; potassium tert-butylate; In tert-Amyl alcohol; at 65 ℃; for 18h; Sealed tube; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.9b00025

Reference yield: 87.0%

→ 5-methyl-benzo[1,2,5]oxadiazole (20304-86-3)

Guidance literature:

upstream raw materials:

4-methyl-2-nitroacetanilide

5-methylbenzofuroxan

4-methyl-1,2-dinitroso-benzene

(4-methyl-2-nitro-phenyl)-(1,2,5-triphenyl-1H-1λ⁵-phosphol-1-ylidene)-amine

Downstream raw materials:

3,6-dimethyl-2-phenylsulfanyl-quinoxaline 1,4-dioxide

2-benzenesulfonyl-3,6-dimethyl-quinoxaline 1,4-dioxide

C₁₇H₁₄N₂O₃

6-methylquinoxaline

Refernces

• 1、 Haydl, Alexander M.,Hartwig, John F.. "Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters". supporting information. p. 1337 - 1341. Retrieved 2019/02/26.
• 2、 -. "New analogs of nitrobenzylthioinosine". Page/Page column 26-27. . Retrieved 2010/11/29.