Ethyl alpha-Formyl Benzeneacetic Acid Ester

Base Information

• Chemical Name: Ethyl alpha-Formyl Benzeneacetic Acid Ester
• CAS No.: 17838-69-6
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2918300090
• Mol file: 17838-69-6.mol

Synonyms:Malonaldehydicacid, phenyl-, ethyl ester (6CI,7CI,8CI);Ethyl 2-formyl-2-phenylacetate;Ethyl formylphenylacetate;Ethylphenylmalonaldehydate;Ethyl a-formylbenzeneacetate;Ethyl a-formylphenylacetate;Formylphenylacetic acid ethyl ester;

Chemical Property of Ethyl alpha-Formyl Benzeneacetic Acid Ester

Chemical Property:

• Melting Point: 50 °C
• Boiling Point: 279.073 °C at 760 mmHg
• PKA: 6.86±0.29(Predicted)
• Flash Point: 119.1 °C
• PSA: 43.37000
• Density: 1.109 g/cm³
• LogP: 1.53220

Purity/Quality:

99%, ^*data from raw suppliers

3-Oxo-2-phenyl-propionicacidethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: Ethyl alpha-formyl benzeneacetic acid ester, a versatile chemical compound, serves various purposes across different fields. In the pharmaceutical industry, it plays a significant role as an intermediate in the synthesis of pharmaceutical compounds and drug candidates. Its chemical structure makes it valuable for creating complex molecules with potential therapeutic effects. In the field of organic chemistry, it serves as a crucial building block for the synthesis of a wide range of organic compounds, including fragrances and flavorings, as well as specialty chemicals used in the production of coatings, adhesives, and polymers. Its versatility and utility as a synthetic intermediate contribute to its importance in chemical research and development. Overall, ethyl alpha-formyl benzeneacetic acid ester is a valuable chemical tool with applications in pharmaceuticals, chemistry, and various other industries.

Technology Process of Ethyl alpha-Formyl Benzeneacetic Acid Ester

There total 12 articles about Ethyl alpha-Formyl Benzeneacetic Acid Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Methyl formate (107-31-3) + Ethyl 2-phenylethanoate (101-97-3) → ethyl 3-oxo-2-phenylpropanoate (17838-69-6)

Guidance literature:

With diisopropyl-carbodiimide; In toluene; at 40 - 50 ℃;

Reference yield: 88.0%

Ethyl 2-phenylethanoate (101-97-3) + formic acid ethyl ester (109-94-4) → ethyl 3-oxo-2-phenylpropanoate (17838-69-6)

Guidance literature:

With sodium; In diethyl ether; for 12h;

DOI:10.1071/C97194

Reference yield: 40.0%

diazoacetic acid ethyl ester (623-73-4) + benzaldehyde (100-52-7) → 3-hydroxy-2-phenylacrylic acid ethyl ester (60734-12-5) + ethyl 3-oxo-3-phenylpropionate (94-02-0) + ethyl 3-oxo-2-phenylpropanoate (17838-69-6)

Guidance literature:

benzaldehyde; With silver hexafluoroantimonate; C₁₆H₁₅AuClN₃⁽¹⁺⁾*Cl^(1-); In chloroform-d1; for 0.25h;

diazoacetic acid ethyl ester; In chloroform-d1; at 20 ℃; for 1h;

DOI:10.1039/c0cc02185g

upstream raw materials:

Ethyl 2-phenylethanoate

formic acid ethyl ester

N-phenylacetyldiphenylamine

diethyl ether

Downstream raw materials:

6-methoxy-3-phenyl-quinolin-4-ol

3-phenyl-quinolin-4-ol

(5-carbamoyl-5-methyl-4-phenyl-thiazolidin-2-yl)-phenyl-acetic acid ethyl ester

2-(ethoxycarbonyl-phenyl-methyl)-5-methyl-4-phenyl-thiazolidine-5-carboxylic acid

Refernces

• 1、 -. "1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS". Paragraph 0883-0884. . Retrieved 2020/11/30.
• 2、 -. "Method for highly efficiently synthesizing 2-phenyl-1,3-propylene glycol". Paragraph 0021-0025; 0027-0031; 0033-0037; 0039-0049. . Retrieved 2018/04/21.