3-ISOPROPOXYANILINE

Base Information

• Chemical Name: 3-ISOPROPOXYANILINE
• CAS No.: 41406-00-2
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2922299090
• Mol file: 41406-00-2.mol

Synonyms:3-(Isopropyloxy)aniline;3-Isopropoxyaniline;3-Isopropoxybenzenamine;m-(Isopropyloxy)aniline;m-Aminophenyl isopropyl ether;m-Isopropoxyaniline;3-(Propan-2-yloxy)aniline;

Chemical Property of 3-ISOPROPOXYANILINE

Chemical Property:

• Vapor Pressure: 0.0131mmHg at 25°C
• Refractive Index: n20/D 1.5500(lit.)
• Boiling Point: 259.2 °C at 760 mmHg
• PKA: 4.54±0.10(Predicted)
• Flash Point: 114.7 °C
• PSA: 35.25000
• Density: 1.014 g/cm³
• LogP: 2.63720
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

m-Isopropoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Uses: m-Isopropoxyaniline is a reactant used in the preparation of [1,2,3]triazolo[4,5-d]pyrimidinones as inhibitors of Chikungunya virus replication.

Technology Process of 3-ISOPROPOXYANILINE

There total 11 articles about 3-ISOPROPOXYANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 3-isopropoxyaniline (41406-00-2)

Guidance literature:

Reference yield: 93.4%

isopropyl chloride (75-29-6) + N,N-dimethyl acetamide (127-19-5,116057-81-9) + m-Hydroxyaniline (591-27-5) → 3-isopropoxyaniline (41406-00-2)

Guidance literature:

With sodium hydroxide;

Reference yield: 71.5%

isopropyl chloride (75-29-6) + diethylene glycol dimethyl ether (111-96-6) + m-Hydroxyaniline (591-27-5) → 3-isopropoxyaniline (41406-00-2)

Guidance literature:

With sodium methylate; In methanol;

upstream raw materials:

3-(1-Methylethoxy)nitrobenzene

(3-Isopropoxy-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

m-Hydroxyaniline

isopropyl bromide

Downstream raw materials:

2-bromo-N-(3-isopropoxyphenyl)acetamide

flutolanil

3,5-dichloro-2,4-difluoro-N-(3-isopropoxyphenyl)-benzamide

ethyl 2-([1,1'-biphenyl]-3-yl)-7-isopropoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate

Refernces

• 1、 Kapustikova, Iva,Bak, Andrzej,Gonec, Tomas,Kos, Jiri,Kozik, Violetta,Jampilek, Josef. "Investigation of hydro-lipophilic properties of n-alkoxyphenylhydroxynaphthalenecarboxamides ?". . . Retrieved 2018/07/10.
• 2、 Gonec, Tomas,Zadrazilova, Iveta,Nevin, Eoghan,Kauerova, Tereza,Pesko, Matus,Kos, Jiri,Oravec, Michal,Kollar, Peter,Coffey, Aidan,O'Mahony, Jim,Cizek, Alois,Kralova, Katarina,Jampilek, Josef. "Synthesis and Biological Evaluation of N-Alkoxyphenyl-3-hydroxynaphthalene-2-carboxanilides". . p. 9767 - 9787. Retrieved 2015/08/06.