2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide

Base Information

• Chemical Name: 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide
• CAS No.: 433728-66-6
• Molecular Formula: C₁₈H₂₀ClN₃O₃
• Molecular Weight: 361.828
• Mol file: 433728-66-6.mol

Synonyms:2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide

Chemical Property of 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide

There total 3 articles about 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) + 2-diisopropylaminocarbonylphenylboronic acid (103681-98-7) → 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide (433728-66-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 80 ℃; for 13h; Inert atmosphere;

Reference yield: 45.0%

2,5-dichloro-3-nitropyridine (21427-62-3) + 2-diisopropylaminocarbonylphenylboronic acid (103681-98-7) → 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide (433728-66-6)

Guidance literature:

2,5-dichloro-3-nitropyridine; 2-diisopropylaminocarbonylphenylboronic acid; With potassium carbonate; In ethanol; water; toluene; for 0.5h;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃;

Reference yield: 42.0%

2,6-dicholoro-3-nitropyridine (16013-85-7,136901-10-5) + 2-diisopropylaminocarbonylphenylboronic acid (103681-98-7) → 2-(6-chloro-5-nitro-pyridin-2-yl)-N,N-diisopropyl-benzamide + 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide (433728-66-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; at 80 ℃;

DOI:10.1021/jm030109s

upstream raw materials:

2,6-dicholoro-3-nitropyridine

2-diisopropylaminocarbonylphenylboronic acid

2,5-dichloro-3-nitropyridine

Downstream raw materials:

2-[3-(nitro)-6-(4-methylpiperazin-1-yl)pyridin-2-yl]-N,N-diisopropylbenzamide

N,N-diisopropyl-2-[6-(4-isopropylpiperazin-1-yl)-3-nitropyridin-2-yl]benzamide

N,N-diisopropyl-2-(6-{[2-(morpholin-4-yl)ethyl]amino}-3-nitropyridin-2-yl)benzamide

N,N-diisopropyl-2-(5'-nitro-4-pyrrolidin-1-yl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-yl)-benzamide

Refernces

• 1、 -. "METHODS AND COMPOSITIONS OF PARP INHIBITORS AS POTENTIATORS IN CANCER THERAPY". Page/Page column 32-33. . Retrieved 2008/06/13.