1-(4-Fluorophenyl)propan-2-amine hydrochloride

Base Information

• Chemical Name: 1-(4-Fluorophenyl)propan-2-amine hydrochloride
• CAS No.: 459-01-8
• Molecular Formula: C₉H₁₂FN*ClH
• Molecular Weight: 189.66
• NSC Number: 93735
• UNII: YIJ78M8D5Q
• DSSTox Substance ID: DTXSID101348050
• Wikidata: Q27294541
• ChEMBL ID: CHEMBL1984078
• Mol file: 459-01-8.mol

Synonyms:1-(2-fluorophenyl)-2-propanamine;2-fluoroamphetamine;4-fluoroamphetamine;4-fluoroamphetamine hydrochloride;4-fluoroamphetamine hydrochloride, (+-)-isomer;4-fluoroamphetamine, (+-)-isomer;4-fluoroamphetamine, (R)-isomer;p-fluoroamphetamine;para-fluoroamphetamine

Chemical Property of 1-(4-Fluorophenyl)propan-2-amine hydrochloride

Chemical Property:

• Boiling Point: 215.2°Cat760mmHg
• Flash Point: 93.6°C
• PSA: 26.02000
• Density: 1.042g/cm³
• LogP: 3.21770
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 189.0720553
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Fluorophenyl)propan-2-aminehydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)F)N.Cl

Technology Process of 1-(4-Fluorophenyl)propan-2-amine hydrochloride

There total 1 articles about 1-(4-Fluorophenyl)propan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (S)-(+)-α-methyl-β-(4-fluorophenyl)ethylamine hydrochloride (127515-13-3,459-01-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

(S)-(+)-α-methyl-β-(4-fluorophenyl)ethylamine hydrochloride (127515-13-3,459-01-8) → (S)‐4‐fluoro‐α‐methylphenethylamine (788123-23-9)

Guidance literature:

With water; sodium hydroxide; at 25 ℃; for 1h;

Reference yield:

(S)-(+)-α-methyl-β-(4-fluorophenyl)ethylamine hydrochloride (127515-13-3,459-01-8) → (S)-6-((1-(4-fluorophenyl)propan-2-yl)amino)-3-isopropylpyrimidine-2,4(1H,3H)-dione

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / 1 h / 25 °C

2: N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / 1-methyl-pyrrolidin-2-one / 5 h / 100 °C

With water; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydroxide; In 1-methyl-pyrrolidin-2-one;

Downstream raw materials:

(S)‐4‐fluoro‐α‐methylphenethylamine

(R)-(-)-α-methyl-β-(4-fluorophenyl)ethylamine

Refernces