N-Boc-3-Methylnipecotic acid ethyl ester

Base Information

• Chemical Name: N-Boc-3-Methylnipecotic acid ethyl ester
• CAS No.: 278789-43-8
• Molecular Formula: C₁₄H₂₅NO₄
• Molecular Weight: 271.357
• Hs Code.: 2933399090
• Mol file: 278789-43-8.mol

Synonyms:1-(tert-Butoxycarbonyl)-3-(ethoxycarbonyl)-3-methylpiperidine;1-tert-Butyl 3-ethyl 3-methylpiperidine-1,3-dicarboxylate;Ethyl1-(tert-butoxycarbonyl)-3-methylpiperidine-3-carboxylate;tert-Butyl3-(ethoxycarbonyl)-3-methylpiperidine-1-carboxylate;

Chemical Property of N-Boc-3-Methylnipecotic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0.000175mmHg at 25°C
• Refractive Index: 1.468
• Boiling Point: 329.7 °C at 760 mmHg
• PKA: -2.37±0.40(Predicted)
• Flash Point: 153.2 °C
• PSA: 55.84000
• Density: 1.054 g/cm³
• LogP: 2.52460
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl1-Boc-3-methylpiperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-3-Methylnipecotic acid ethyl ester

There total 5 articles about N-Boc-3-Methylnipecotic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) + methyl iodide (74-88-4) → ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate (278789-43-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 18h;

Reference yield: 82.0%

ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate (191599-51-6) + methyl iodide (74-88-4) → ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate (278789-43-8)

Guidance literature:

ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate; With lithium diisopropyl amide; In tetrahydrofuran;

methyl iodide; In tetrahydrofuran;

Reference yield:

lithium diisopropylamide [LDA] + ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) → ethyl N-t-butyloxycarbonyl-3-methylpiperidine-3-carboxylate (278789-43-8)

Guidance literature:

With methyl iodide; In tetrahydrofuran;

upstream raw materials:

ethyl N-(t-butyloxycarbonyl)nipecotate

methyl iodide

di-tert-butyl dicarbonate

Ethyl nipecotate

Downstream raw materials:

3-methylpiperidine-3-carboxylic acid ethyl ester

C₁₆H₂₃NO₃

C₁₆H₂₃NO₃

C₁₆H₂₃NO₃

Refernces

• 1、 -. "PHARMACOLOGICALLY ACTIVE ARYL-SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES". Page/Page column 24-25. . Retrieved 2018/10/19.
• 2、 -. "2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF". . . Retrieved 2016/01/25.