N-Methyl-1-(methylsulfonyl)piperidin-4-amine

Base Information

• Chemical Name: N-Methyl-1-(methylsulfonyl)piperidin-4-amine
• CAS No.: 438585-61-6
• Molecular Formula: C7H16 N2 O2 S
• Molecular Weight: 192.282
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID201258955
• Mol file: 438585-61-6.mol

Synonyms:438585-61-6;N-Methyl-1-(methylsulfonyl)piperidin-4-amine;1-N-(Methylsulfonyl)-4-(aminomethyl)piperidine;N-methyl-1-methylsulfonylpiperidin-4-amine;1-methanesulfonyl-N-methylpiperidin-4-amine;4-(Methylamino)-1-(methylsulphonyl)piperidine;SCHEMBL5344959;VCBIBMMEIOUYBB-UHFFFAOYSA-N;DTXSID201258955;MFCD08061933;AKOS009820513;SB41732;TS-02731;DB-070485;CS-0106568;N-methyl-1-(methylsulfonyl)-4-Piperidinamine;D76650;EN300-148484;N-Methyl-1-(methylsulfonyl)-4-piperidineamine;1-N-(Methylsulfonyl)-4-(Methylamino)piperidine;A826447;J-523639

Chemical Property of N-Methyl-1-(methylsulfonyl)piperidin-4-amine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 302.577°C at 760 mmHg
• PKA: 9.76±0.20(Predicted)
• Flash Point: 136.794°C
• PSA: 57.79000
• Density: 1.196g/cm³
• LogP: 1.03940
• Storage Temp.: 2-8°C
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 192.09324893
• Heavy Atom Count: 12
• Complexity: 224

Purity/Quality:

98%min ^*data from raw suppliers

4-(Methylamino)-1-(methylsulfonyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1CCN(CC1)S(=O)(=O)C

Technology Process of N-Methyl-1-(methylsulfonyl)piperidin-4-amine

There total 2 articles about N-Methyl-1-(methylsulfonyl)piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-Methylsuylfonyl-4-piperidone + 1-(methylsulfonyl)piperidin-4-one (218780-53-1) → N-methyl‐1‐(methylsulphonyl)piperidin‐4‐amine (438585-61-6)

Guidance literature:

With aq. NaOH; NaBH(OAc)3; CH₃NH₂; In acetonitrile;

Reference yield: 62.9%

methylamine (74-89-5) + 1-(methylsulfonyl)piperidin-4-one (218780-53-1) → N-methyl‐1‐(methylsulphonyl)piperidin‐4‐amine (438585-61-6)

Guidance literature:

methylamine; 1-(methylsulfonyl)piperidin-4-one; In acetonitrile; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In acetonitrile; at -10 - 20 ℃;

With sodium hydroxide; In water;

Reference yield: 71.0%

N-methyl‐1‐(methylsulphonyl)piperidin‐4‐amine (438585-61-6) + C16H11F2N3O2 → C17H21F2N5O3S

Guidance literature:

With triethylamine; In chloroform; Heating / reflux;

upstream raw materials:

methylamine

1-(methylsulfonyl)piperidin-4-one

Refernces

• 1、 -. "Neuropeptide Y Y5 receptor antagonists". . . Retrieved 2008/06/13.