1H-indol-1-yl benzoate

Base Information

• Chemical Name: 1H-indol-1-yl benzoate
• CAS No.: 86531-02-4
• Molecular Formula: C₁₅H₁₁NO₂
• Molecular Weight: 237.258
• Mol file: 86531-02-4.mol

Synonyms:1H-indol-1-yl benzoate

Chemical Property of 1H-indol-1-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1H-indol-1-yl benzoate

There total 5 articles about 1H-indol-1-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-hydroxyindole (3289-82-5) + benzoyl chloride (98-88-4) → 1H-indol-1-yl benzoate (86531-02-4)

Guidance literature:

With potassium carbonate; In benzene; Ambient temperature;

Reference yield:

1-indoline (496-15-1) → 1H-indol-1-yl benzoate (86531-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaWO₄, 30percent H₂O₂ / methanol

2: 49 percent / K₂CO₃ / benzene / Ambient temperature

With sodium tungstate; dihydrogen peroxide; potassium carbonate; In methanol; benzene;

Reference yield:

(2-nitrophenyl)acetaldehyde (1969-73-9) → 1-benzoyloxyindole (86531-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn/ammonium chloride / diethyl ether; H₂O

2: 3.9 g / pyridine / diethyl ether / 4 h / Ambient temperature

With pyridine; ammonium chloride; zinc; In diethyl ether; water;

DOI:10.1039/P29830000497

upstream raw materials:

1-hydroxyindole

benzoyl chloride

1-indoline

N,N-dimethyl-2-(2-nitrophenyl)ethenylamine

Downstream raw materials:

(S)-1-(1-phenylethyl)-1H-indole

1H-indol-2-ylcarboxaldehyde

2-(hydroxymethyl)indole

α-methyl-α-phenyl-1-(methoxymethoxy)indole-2-methanol

Refernces

• 1、 Ye, Yuxuan,Kim, Seoung-Tae,Jeong, Jinhoon,Baik, Mu-Hyun,Buchwald, Stephen L.. "CuH-Catalyzed Enantioselective Alkylation of Indole Derivatives with Ligand-Controlled Regiodivergence". supporting information. p. 3901 - 3909. Retrieved 2019/03/12.