2-Amino-4-chloro-2'-fluorobenzophenone

Base Information

• Chemical Name: 2-Amino-4-chloro-2'-fluorobenzophenone
• CAS No.: 203303-05-3
• Molecular Formula: C13H9 Cl F N O
• Molecular Weight: 249.672
• Hs Code.: 2922390090
• European Community (EC) Number: 670-941-5
• DSSTox Substance ID: DTXSID00371000
• Wikidata: Q82158207
• Mol file: 203303-05-3.mol

Synonyms:203303-05-3;2-Amino-4-chloro-2'-fluorobenzophenone;(2-Amino-4-chlorophenyl)(2-fluorophenyl)methanone;(2-amino-4-chlorophenyl)-(2-fluorophenyl)methanone;Methanone,(2-amino-4-chlorophenyl)(2-fluorophenyl)-;SCHEMBL1342161;DTXSID00371000;OBXGOBSNRWWAOU-UHFFFAOYSA-N;MFCD00236584;PC7608;AKOS009158525;SB80628;CS-0449328;FT-0643897;A814455;J-500622;(2-amino-4-chloro-phenyl)-(2-fluoro-phenyl)-methanone

Chemical Property of 2-Amino-4-chloro-2'-fluorobenzophenone

Chemical Property:

• Vapor Pressure: 1.13E-07mmHg at 25°C
• Boiling Point: 432.2°C at 760 mmHg
• Flash Point: 215.2°C
• PSA: 43.09000
• Density: 1.342g/cm³
• LogP: 3.87350
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 249.0356698
• Heavy Atom Count: 17
• Complexity: 287

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-4-chloro-2'-fluorobenzophenone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)C2=C(C=C(C=C2)Cl)N)F

Technology Process of 2-Amino-4-chloro-2'-fluorobenzophenone

There total 1 articles about 2-Amino-4-chloro-2'-fluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.6%

2-fluorobenzonitrile (394-47-8) + 3-chloro-aniline (108-42-9) → 2-amino-4-chlorophenyl-(2-fluorophenyl)methanone (203303-05-3)

Guidance literature:

With gallium(III) trichloride; boron trichloride; In dichloromethane; 1,2-dichloro-ethane; at -10 - 80 ℃; for 18h; Inert atmosphere;

Reference yield: 64.0%

2-amino-4-chlorophenyl-(2-fluorophenyl)methanone (203303-05-3) + (2aS,6aR,14bS)-2a-methyl-3,4,6,6a,8,9,14,14b-octahydro-1H-benzo[5′,6′][1,4]oxazino[4′,3′:1,2]pyrido[3,4-b]indol-5(2aH)-one → (5bS,7aS,15bR)-12-chloro-15-(2-fluorophenyl)-7a-methyl-5b,6,7a,8,9,15b,17,18-octahydro-5H-indolo[2″,3″:3′,4′]pyrido-[1′,2′:4,5][1,4]oxazino[3,2-a]acridine

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 ℃; for 24h;

DOI:10.1021/acs.joc.1c02698

Reference yield: 63.0%

2-amino-4-chlorophenyl-(2-fluorophenyl)methanone (203303-05-3) + (2aR,6aR,14bS)-2a-methoxy-2,2a,3,4,6,6a,8,9,14,14b-decahydroindolo[2′,3′:3,4]pyrido[1,2-a]quinolin-5(1H)-one → (5bS,7aR,15aR)-11-chloro-9-(2-fluorophenyl)-7a-methoxy-5,5b,6,7,7a,8,15,15a,17,18-decahydroindolo[3′,2′:8,9]quinolizino-[3,4-b]acridine

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 20 ℃; for 24h;

DOI:10.1021/acs.joc.1c02698

upstream raw materials:

2-fluorobenzonitrile

3-chloro-aniline

Refernces