N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PYRROLIDINE

Base Information

• Chemical Name: N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PYRROLIDINE
• CAS No.: 133184-80-2
• Molecular Formula: C11H13F3N2
• Molecular Weight: 230.233
• Hs Code.: 2933990090
• Mol file: 133184-80-2.mol

Synonyms:N-[2-Amino-4-(trifluoromethyl)phenyl]pyrrolidine;

Chemical Property of N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PYRROLIDINE

Chemical Property:

• Vapor Pressure: 0.00022mmHg at 25°C
• Melting Point: 33 °C
• Refractive Index: 1.604
• Boiling Point: 315.4 °C at 760 mmHg
• PKA: 5.51±0.40(Predicted)
• Flash Point: 144.5 °C
• PSA: 29.26000
• Density: 1.28 g/cm³
• LogP: 3.53400
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Pyrrolidin-1-yl-5-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36

MSDS Files:

Useful:

Technology Process of N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PYRROLIDINE

There total 2 articles about N-(2-AMINO-4-TRIFLUOROMETHYLPHENYL)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(2-nitro-4-(trifluoromethyl)phenyl)pyrrolidine (40832-82-4) → 2-(pyrrolidin-1-yl)-5-(trifluoromethyl)aniline (133184-80-2)

Guidance literature:

1-(2-nitro-4-(trifluoromethyl)phenyl)pyrrolidine; With hydrogenchloride; tin(ll) chloride; In methanol; at 0 ℃; for 4h;

With water; sodium hydrogencarbonate; In methanol;

Reference yield:

1-fluoro-2-nitro-4-trifluoromethyl-benzene (367-86-2) → 2-(pyrrolidin-1-yl)-5-(trifluoromethyl)aniline (133184-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

2: tin(ll) chloride; hydrogenchloride / methanol / 42 h / 0 - 20 °C

With hydrogenchloride; tin(ll) chloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2017.03.078

Reference yield: 97.8%

2-(pyrrolidin-1-yl)-5-(trifluoromethyl)aniline (133184-80-2) + isonicotinoyl chloride hydrochloride (39178-35-3) → N-(2-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

upstream raw materials:

1-(2-nitro-4-(trifluoromethyl)phenyl)pyrrolidine

1-fluoro-2-nitro-4-trifluoromethyl-benzene

Downstream raw materials:

1-phenyl-N-[2-(1-pyrrolidinyl)-5-(trifluoromethyl)phenyl]cyclopropane-carboxamide

Refernces

• 1、 Yang, Shuo,An, Xiao-De,Qiu, Bin,Liu, Rui-Bin,Xiao, Jian. "Access to Polycyclic Indole-3,4-Fused Nine-Membered Ring via Cascade 1,6-Hydride Transfer/Cyclization". supporting information. p. 9100 - 9105. Retrieved 2021/11/24.
• 2、 Siqueira, Raoni Pais,Barros, Marcus Vinícius de Andrade,Barbosa, éverton de Almeida Alves,Onofre, Thiago Souza,Gon?alves, Victor Hugo Sousa,Pereira, Higor Sette,Silva Júnior, Abelardo,de Oliveira, Leandro Licursi,Almeida, Márcia Rogéria,Fietto, Juliana Lopes Rangel,Teixeira, Róbson Ricardo,Bressan, Gustavo Costa. "Trifluoromethyl arylamides with antileukemia effect and intracellular inhibitory activity over serine/arginine-rich protein kinases (SRPKs)". . p. 97 - 109. Retrieved 2017/04/13.