N-BENZYLISATOIC ANHYDRIDE

Base Information

• Chemical Name: N-BENZYLISATOIC ANHYDRIDE
• CAS No.: 35710-05-5
• Molecular Formula: C15H11 N O3
• Molecular Weight: 253.257
• Hs Code.: 2934999090
• Mol file: 35710-05-5.mol

Synonyms:2H-3,1-Benzoxazine-2,4(1H)-dione,1-benzyl- (7CI); Isatoic anhydride, N-benzyl- (6CI); 1-(Phenylmethyl)-2H-3,1-Benzoxazine-2,4(1H)-dione;1-Benzyl-1H-benzo[d][1,3]oxazine-2,4-dione;1-Benzylbenzo[d][1,3]oxazine-2,4-dione; 1-Benzylisatoic anhydride;N-Benzylisatoic acid anhydride; N-Benzylisatoic anhydride

Chemical Property of N-BENZYLISATOIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 3.03E-07mmHg at 25°C
• Melting Point: 136 °C
• Boiling Point: 419.5°Cat760mmHg
• Flash Point: 207.5°C
• PSA: 52.21000
• Density: 1.335g/cm³
• LogP: 2.00300

Purity/Quality:

98%min ^*data from raw suppliers

N-Benzylisatoic anhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BENZYLISATOIC ANHYDRIDE

There total 11 articles about N-BENZYLISATOIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

isatoic anhydride (118-48-9) + benzyl bromide (100-39-0) → N-benzylisatoic anhydride (35710-05-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 80 ℃; for 3h;

DOI:10.1021/acs.joc.9b02541

Reference yield: 95.0%

carbon dioxide (124-38-9,18923-20-1) + carbon monoxide (201230-82-2) + N-benzyl-2-iodoaniline (76464-99-8) → N-benzylisatoic anhydride (35710-05-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium acetate; In tetrahydrofuran; at 60 ℃; for 16h;

DOI:10.1021/acscatal.7b03000

Reference yield: 75.0%

1-benzylisatin (1217-89-6) → N-benzylisatoic anhydride (35710-05-5)

Guidance literature:

With diphenyl diselenide; dihydrogen peroxide; In acetonitrile; at 25 ℃; for 8h; Solvent; Schlenk technique; Green chemistry;

DOI:10.1039/c5cy01030f

upstream raw materials:

phosgene

N-benzylanthranilic acid

isatoic anhydride

benzyl alcohol

Downstream raw materials:

Benzyl-[2-(5-phenyl-[1,3,4]oxadiazol-2-yl)-phenyl]-amine

Benzoic acid N'-(2-benzylamino-benzoyl)-hydrazide

2-Benzylamino-N-(2-hydroxy-butyl)-benzamide

N-benzyl-2-(5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)aniline

Refernces

• 1、 Bieszczad, Bartosz,Garbicz, Damian,Trzybiński, Damian,Mielecki, Damian,Wo?niak, Krzysztof,Grzesiuk, El?bieta,Mieczkowski, Adam. "Unsymmetrically substituted dibenzo[b,f][1,5]-diazocine-6,12(5H,11H)dione—A convenient scaffold for bioactive molecule design". . . Retrieved 2020/02/22.
• 2、 Wang, Shoucai,Li, Xuan,Zang, Jiawang,Liu, Meichen,Zhang, Siyu,Jiang, Guangbin,Ji, Fanghua. "Palladium-Catalyzed Multistep Tandem Carbonylation/N-Dealkylation/Carbonylation Reaction: Access to Isatoic Anhydrides". . p. 2672 - 2679. Retrieved 2020/02/04.