3-Benzyloxybenzhydrazide

Base Information

• Chemical Name: 3-Benzyloxybenzhydrazide
• CAS No.: 228419-13-4
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• Hs Code.: 2928000090
• European Community (EC) Number: 673-550-8
• DSSTox Substance ID: DTXSID10370746
• Nikkaji Number: J1.816.357H
• Wikidata: Q82157899
• Mol file: 228419-13-4.mol

Synonyms:3-Benzyloxybenzhydrazide;228419-13-4;3-(benzyloxy)benzohydrazide;3-phenylmethoxybenzohydrazide;3-benzyloxybenzohydrazide;Benzoic acid, 3-(phenylmethoxy)-, hydrazide;SCHEMBL7410475;DTXSID10370746;MFCD01310784;AKOS005288739;SB86311;AS-59221;CS-0328283;FT-0682062;D95766;A816386;F1905-7032

Chemical Property of 3-Benzyloxybenzhydrazide

Chemical Property:

• Melting Point: 113 °C
• Refractive Index: 1.61
• PSA: 64.35000
• Density: 1.201 g/cm³
• LogP: 2.96030
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

99% ^*data from raw suppliers

3-Benzyloxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:对眼睛、呼吸道和皮肤有刺激作用
• Hazard Codes: R36/37/38:对眼睛、呼吸道和皮肤有刺激作用
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC(=C2)C(=O)NN

Technology Process of 3-Benzyloxybenzhydrazide

There total 7 articles about 3-Benzyloxybenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 3-(benzyloxy)benzoate (63888-94-8) → 3-(benzyloxy)benzoic acid hydrazide (228419-13-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 28h; Heating;

DOI:10.1002/1522-2675(200202)85:2<559::AID-HLCA559>3.0.CO;2-A

Reference yield:

benzyl bromide (100-39-0) → 3-(benzyloxy)benzoic acid hydrazide (228419-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃ / acetone / 2 h / Heating

2: 88 percent / hydrazine hydrate / ethanol / 5 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1016/S0968-0896(02)00611-9

Reference yield:

methyl 3-hydroxybenzoate (19438-10-9) → 3-(benzyloxy)benzoic acid hydrazide (228419-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / K₂CO₃ / acetone / 2 h / Heating

2: 88 percent / hydrazine hydrate / ethanol / 5 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1016/S0968-0896(02)00611-9

upstream raw materials:

ethyl 3-(benzyloxy)benzoate

methyl 3-hydroxybenzoate

benzyl bromide

ethyl-3-hydroxybenzoate

Downstream raw materials:

5-(3-benzyloxyphenyl)-1,3,4-oxadiazol-2-one

2-(3-hydroxyphenyl)-1,3,4-oxadiazole

2-(3-hydroxyphenyl)-1,3,4-oxadiazol-5-one

5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione

Refernces

• 1、 Ghani, Usman,Ullah, Nisar. "New potent inhibitors of tyrosinase: Novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site". scheme or table. p. 4042 - 4048. Retrieved 2010/08/06.
• 2、 Khan, Khalid Mohammed,Rahat, Shagufta,Choudhary, Muhammad Iqbal,Atta-ur-Rahman,Ghani, Usman,Perveen, Shahnaz,Khatoon, Shagufta,Dar, Ahsana,Malik, Abdul. "Synthesis and biological screening of 2-substituted 5,6-dihydro-5-oxo-4H-1,3,4-oxadiazine-4-propanenitriles and of their intermediates". . p. 559 - 570. Retrieved 2007/10/03.