Benzyl-pyridin-2-ylmethyl-amine

Base Information

• Chemical Name: Benzyl-pyridin-2-ylmethyl-amine
• CAS No.: 18081-89-5
• Molecular Formula: C13H14N2
• Molecular Weight: 198.268
• Hs Code.: 2933399090
• European Community (EC) Number: 673-490-2
• Nikkaji Number: J830.498J
• Mol file: 18081-89-5.mol

Synonyms:Benzyl-pyridin-2-ylmethyl-amine;18081-89-5;N-Benzyl-1-(pyridin-2-yl)methanamine;Benzylpyridin-2-ylmethylamine;1-phenyl-N-(pyridin-2-ylmethyl)methanamine;2-Pyridinemethanamine, N-(phenylmethyl)-;benzyl(2-pyridylmethyl)amine;SCHEMBL2947235;HMS1704A05;MFCD03425010;STL417165;AKOS000226422;SB54122;AM803395;AS-39473;BB 0258173;CS-0038258;FT-0637644

Chemical Property of Benzyl-pyridin-2-ylmethyl-amine

Chemical Property:

• Vapor Pressure: 0.412mmHg at 25°C
• Refractive Index: 1.455
• Boiling Point: 313.1 °C at 760 mmHg
• Flash Point: 143.2 °C
• PSA: 24.92000
• Density: 1.071 g/cm³
• LogP: 2.76230
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 198.115698455
• Heavy Atom Count: 15
• Complexity: 164

Purity/Quality:

98%min ^*data from raw suppliers

Benzyl-pyridin-2-ylmethyl-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNCC2=CC=CC=N2

Technology Process of Benzyl-pyridin-2-ylmethyl-amine

There total 36 articles about Benzyl-pyridin-2-ylmethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(Aminomethyl)pyridine (3731-51-9) + benzaldehyde (100-52-7) → 2-(N-benzylaminomethyl)pyridine (18081-89-5)

Guidance literature:

2-(Aminomethyl)pyridine; benzaldehyde; In methanol; at 20 ℃; for 2h;

With methanol; sodium tetrahydroborate; at 20 ℃; for 1h; Cooling with ice;

Reference yield: 99.0%

pyridine-2-carbaldehyde (1121-60-4) + benzylamine (100-46-9) → 2-(N-benzylaminomethyl)pyridine (18081-89-5)

Guidance literature:

pyridine-2-carbaldehyde; benzylamine; In ethanol; at 50 ℃; for 24h;

With sodium tetrahydroborate; ethanol; at 50 ℃; for 96h;

Reference yield: 96.0%

2-(Aminomethyl)pyridine (3731-51-9) + benzyl alcohol (100-51-6,185532-71-2) → 2-(N-benzylaminomethyl)pyridine (18081-89-5)

Guidance literature:

With Ru₃(2-(2-hydroxoethyl)pyridine)₂(CO)₈; potassium tert-butylate; In toluene; at 110 ℃; for 24h; Reagent/catalyst; Time; Catalytic behavior; Molecular sieve; Inert atmosphere;

DOI:10.1039/c8dt02972e

upstream raw materials:

1-phenyl-N-(pyridin-2-ylmethylene)methanamine

1-Benzyl-1,4-dihydronicotinamide

1-benzyl-3-carbamoyl-1,4-dihydroquinoline

diethyl ((benzylamino)(pyridin-2-yl)methyl)phosphonate

Downstream raw materials:

2,4-di-tert-butyl-6-{[2'-(pyridin-2-yl)benzylamino]methyl}-phenol

C₄₁H₄₄N₄O

N-(2-pyridylmethyl)-benzylamine oxalate

2-((N-benzylpyrid-2-ylmethylamino)methyl)-4,6-dimethylphenol

Refernces

• 1、 Shinkai, Seiji,Hamada, Hisatake,Dohyama, Akihiko,Manabe, Osamu. "NADH MODEL REDUCTION: BIOMIMETIC SYNTHESIS OF α-AMINO ACIDS FROM α-KETO ACIDS". . p. 1661 - 1664. Retrieved 1980.
• 2、 Shirvan, Atie,Golchoubian, Hamid,Bouwman, Elisabeth. "Syntheses and chromotropic behavior of two halo bridged dinuclear copper(II) complexes containing pyridine-based bidentate ligand". . p. 769 - 777. Retrieved 2019.
• 3、 Spencer, Douglas J. E.,Johnson, Bryan J.,Johnson, Brian J.,Tolman, William B.. "Calix[4]arenes Linked to Multiple Bidentate N-Donors: Potential Ligands for Synthetic Modeling of Multinuclear Metalloenzymes". . p. 1391 - 1393. Retrieved 2002.
• 4、 Sarkar, Koushik,Das, Kuhali,Kundu, Abhishek,Adhikari, Debashis,Maji, Biplab. "Phosphine-Free Manganese Catalyst Enables Selective Transfer Hydrogenation of Nitriles to Primary and Secondary Amines Using Ammonia-Borane". . p. 2786 - 2794. Retrieved 2021/03/03.