N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride

Base Information

• Chemical Name: N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride
• CAS No.: 79664-26-9
• Molecular Formula: C₂₂H₄₆N₄*4ClH
• Molecular Weight: 512.478
• Mol file: 79664-26-9.mol

Synonyms:N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride

Chemical Property of N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride

There total 2 articles about N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N,N'-bis[3-(cyclohexyl(2-nitrobenzenesulfonyl)amino)propyl]-N,N'-bis(2-nitrobenzenesulfonyl)butane-1,4-diamine (1111644-24-6) → N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride (79664-26-9)

Guidance literature:

N,N'-bis[3-(cyclohexyl(2-nitrobenzenesulfonyl)amino)propyl]-N,N'-bis(2-nitrobenzenesulfonyl)butane-1,4-diamine; With potassium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.tet.2008.10.071

Reference yield:

Spermine (71-44-3) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N,N'-bis[3-(cyclohexylamino)propyl]butane-1,4-diamine tetrahydrochloride (79664-26-9)

Guidance literature:

With hydrogenchloride; hydrogen; Yield given. Multistep reaction; 1) 95percent EtOH, 15 h, 2) 95percent EtOH, 20 to 25 deg C, 1 to 3 atm, 72 h;

DOI:10.1021/jo00338a042

upstream raw materials:

Spermine

cyclohexanone

N,N'-bis[3-(cyclohexyl(2-nitrobenzenesulfonyl)amino)propyl]-N,N'-bis(2-nitrobenzenesulfonyl)butane-1,4-diamine

Refernces

• 1、 Weitl, Frederick L.,Raymond, kenneth M.. "Lipophilic Enterobactin Analogues. Terminally N-alkylated Spermine/Spermidine Catecholcarboxamides". . p. 5234 - 5237. Retrieved 2007/10/02.