4-Bromo-2-chlorobenzohydrazide

Base Information

• Chemical Name: 4-Bromo-2-chlorobenzohydrazide
• CAS No.: 206559-39-9
• Molecular Formula: C₇H₆BrClN₂O
• Molecular Weight: 249.494
• Hs Code.: 2928000090
• European Community (EC) Number: 673-536-1
• DSSTox Substance ID: DTXSID70370782
• Wikidata: Q82157946
• Mol file: 206559-39-9.mol

Synonyms:4-bromo-2-chlorobenzohydrazide;4-Bromo-2-chlorobenzhydrazide;206559-39-9;C7H6BrClN2O;SCHEMBL3135059;DTXSID70370782;MFCD00270095;AKOS009158377;SB86013;Benzoicacid,4-bromo-2-chloro-,hydrazide;BS-22019;Benzoic acid, 4-bromo-2-chloro-, hydrazide;CS-0205923;FT-0682064;EN300-68851;A814774

Chemical Property of 4-Bromo-2-chlorobenzohydrazide

Chemical Property:

• Melting Point: 173 ºC
• Refractive Index: 1.626
• PSA: 55.12000
• Density: 1.719 g/cm³
• LogP: 2.79720
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 247.93520
• Heavy Atom Count: 12
• Complexity: 179

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-chlorobenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Br)Cl)C(=O)NN

Technology Process of 4-Bromo-2-chlorobenzohydrazide

There total 2 articles about 4-Bromo-2-chlorobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-bromo-2-chlorobenzoic acid methyl ester (185312-82-7) → 4-bromo-2-chlorobenzohydrazide (206559-39-9)

Guidance literature:

With hydrazine hydrate; In methanol; at 85 ℃; for 14h;

DOI:10.1021/acs.jmedchem.8b01772

Reference yield:

4-Bromo-2-chloro-benzoic Acid (59748-90-2) → 4-bromo-2-chlorobenzohydrazide (206559-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 85 °C

2: hydrazine hydrate / methanol / 14 h / 85 °C

With sulfuric acid; hydrazine hydrate; In methanol;

DOI:10.1021/acs.jmedchem.8b01772

upstream raw materials:

4-Bromo-2-chloro-benzoic Acid

4-bromo-2-chlorobenzoic acid methyl ester

Refernces