3-CHLORO-2,6-DIFLUOROBENZALDEHYDE

Base Information

• Chemical Name: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE
• CAS No.: 190011-87-1
• Molecular Formula: C7H3ClF2O
• Molecular Weight: 176.55
• Hs Code.: 29130000
• Mol file: 190011-87-1.mol

Synonyms:3-CHLORO-2,6-DIFLUOROBENZALDEHYDE;TIMTEC-BB SBB003775

Chemical Property of 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.221mmHg at 25°C
• Melting Point: 46-49 °C(lit.)
• Refractive Index: 1.536
• Boiling Point: 207.833 °C at 760 mmHg
• Flash Point: 79.495 °C
• PSA: 17.07000
• Density: 1.453 g/cm³
• LogP: 2.43070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-2,6-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE

There total 3 articles about 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3-chloro-2,6-difluoro-phenyl)-methanol (252004-35-6) → 1-(3-chloro-2,6-difluoro-phenyl)-carboxaldehyde (190011-87-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 2h;

Reference yield:

1-chloro-2,4-difluorobenzene (1435-44-5) → 1-(3-chloro-2,6-difluoro-phenyl)-carboxaldehyde (190011-87-1)

Guidance literature:

With lithium diisopropyl amide; In DMF (N,N-dimethyl-formamide);

Reference yield:

4-morpholinecarboxaldehyde (4394-85-8) + n-butyllithium (109-72-8,29786-93-4) + 1-chloro-2,4-difluorobenzene (1435-44-5) → 1-(3-chloro-2,6-difluoro-phenyl)-carboxaldehyde (190011-87-1)

Guidance literature:

With diisopropylamine; In tetrahydrofuran; hexane;

upstream raw materials:

1-chloro-2,4-difluorobenzene

4-morpholinecarboxaldehyde

n-butyllithium

(3-chloro-2,6-difluoro-phenyl)-methanol

Downstream raw materials:

(E)-3-(3-chloro-2,6-difluoro-phenyl)acrylic acid

4-chloro-5-(3-chloro-2,6-difluorophenyl)-1-(4-chlorophenyl)-2-methyl-1H-imidazole

Refernces

• 1、 -. "2″-deoxy hygromycin derivatives". Page column 32. . Retrieved 2008/06/13.