C₁₉H₂₀O₅

Base Information

• Chemical Name: C₁₉H₂₀O₅
• CAS No.: 1376220-55-1
• Molecular Formula: C₁₉H₂₀O₅
• Molecular Weight: 328.365
• Mol file: 1376220-55-1.mol

Synonyms:C₁₉H₂₀O₅

Chemical Property of C₁₉H₂₀O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₀O₅

There total 5 articles about C₁₉H₂₀O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate (1376220-54-0) → C19H20O5 (1376220-55-1,115025-90-6)

Guidance literature:

With potassium hydroxide; In ethanol; Reflux;

DOI:10.1016/j.bmcl.2012.03.093

Reference yield:

1-Chloromethylnaphthalene (86-52-2) → C19H20O5 (1376220-55-1,115025-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 40 °C

1.2: 3 h / 80 °C

2.1: potassium hydroxide / ethanol / Reflux

With sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.093

Reference yield:

(R)-(tetrahydrofuran-2-yl)methanol (97-99-4,22415-59-4,57203-01-7,72074-94-3) → C19H20O5 (1376220-55-1,115025-90-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 3 h / 0 °C

2.1: sodium ethanolate / 2 h / 20 °C

2.2: 28 h / 20 - 78 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 40 °C

3.2: 3 h / 80 °C

4.1: potassium hydroxide / ethanol / Reflux

With pyridine; sodium ethanolate; sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.093

upstream raw materials:

(R)-diethyl 2-[(naphthalen-1-yl)methyl]-3-(tetrahydrofuran-2-yl)malonate

1-Chloromethylnaphthalene

(R)-(tetrahydrofuran-2-yl)methanol

[(2R)-tetrahydrofuran-2-yl]methyl 4-methylbenzenesulfonate

Downstream raw materials:

(R)-3-Naphthalen-1-yl-2-[(R)-1-(tetrahydro-furan-2-yl)methyl]-propionic acid 2-diethylamino-ethyl ester; compound with oxalic acid

(S)-3-Naphthalen-1-yl-2-[(R)-1-(tetrahydro-furan-2-yl)methyl]-propionic acid 2-diethylamino-ethyl ester; compound with oxalic acid

(2R,2'R)-acide 2-<(naphth-1-yl)methyl>-3-(tetrahydrofur-2-yl)propanoique

(2S,2'R)-acide 2-<(naphth-1-yl)methyl>-3-(tetrahydrofur-2-yl)propanoique

Refernces